{"id":"W2136922245","doi":"10.1139/cjpp-2014-0521","title":"Development of a high throughput luciferase reporter gene system for screening activators and repressors of human collagen Iα2 gene expression","year":2015,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital","funders":"Canadian Institutes of Health Research; National Institutes of Health; Research Manitoba","keywords":"CTGF; Pirfenidone; Luciferase; Fibroblast; Fibrosis; Cancer research; Gene silencing; Gene expression; Biology; Cell biology; Reporter gene; Cell culture; Transcription factor; Lysyl oxidase; High-throughput screening; Extracellular matrix; Gene; Bioinformatics; Medicine; Transfection; Growth factor; Genetics; Pathology; Internal medicine; Idiopathic pulmonary fibrosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000488273,0.0001211413,0.0003529286,0.0001350242,0.0001124407,0.000003737726,0.0001350528,0.0001548467,0.00002646793],"category_scores_gemma":[0.00007843531,0.0001102467,0.00004772174,0.00005309525,0.000220561,0.000009550365,0.00006452787,0.00007896948,8.319128e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003783817,"about_ca_system_score_gemma":0.000658314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002377002,"about_ca_topic_score_gemma":0.000219927,"domain_scores_codex":[0.9988779,0.0001662329,0.0004268205,0.0002265168,0.0000704203,0.0002320393],"domain_scores_gemma":[0.9987017,0.00004425687,0.0004052013,0.000117662,0.0003778403,0.0003533712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004703838,0.00001687526,0.002930547,0.0001176024,0.0002208498,0.0000229043,0.000448314,0.00003353459,0.9948282,0.00001422292,0.0006104422,0.0002861297],"study_design_scores_gemma":[0.001501283,0.0005292291,0.005661596,0.00002729231,0.00004528664,0.0001030978,0.0002421437,0.000007315192,0.9903191,0.00005968645,0.001406241,0.00009770525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981501,0.0008499463,0.0004869988,0.0000386416,0.0002000035,0.0002190646,0.00003801626,0.000001298966,0.00001595677],"genre_scores_gemma":[0.9971402,0.00001578367,0.002560674,0.00002998704,0.0001780566,0.0000135684,0.00002523863,0.0000134301,0.00002311779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004509069,"threshold_uncertainty_score":0.4495731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05056030894718033,"score_gpt":0.3294382412175918,"score_spread":0.2788779322704115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}