{"id":"W2137053703","doi":"10.1517/17460441.3.6.677","title":"Strategies to assess blood–brain barrier penetration","year":2008,"lang":"en","type":"article","venue":"Expert Opinion on Drug Discovery","topic":"Pharmacological Effects and Toxicity Studies","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Blood–brain barrier; Penetration (warfare); Medicine; Neuroscience; Biology; Computational biology; Central nervous system; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001354438,0.0002095564,0.0003047988,0.0000937419,0.0002256892,0.00006009523,0.00009349248,0.0000636656,0.0001831149],"category_scores_gemma":[0.0001714528,0.0001505288,0.0001142171,0.0001644363,0.00008589282,0.000373266,0.00006067185,0.0001762382,0.00008004159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004947842,"about_ca_system_score_gemma":0.0001146812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004168442,"about_ca_topic_score_gemma":0.000004803546,"domain_scores_codex":[0.998705,0.00008474114,0.0002126739,0.0003586571,0.0003677159,0.0002712246],"domain_scores_gemma":[0.9992792,0.0002381697,0.0000443566,0.0002038446,0.00004796333,0.0001864638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001243696,0.002062511,0.003530435,0.00007994164,0.0003670586,0.0003040522,0.00461654,0.0004688925,0.3085694,0.009151192,0.667039,0.002567267],"study_design_scores_gemma":[0.007753732,0.004770434,0.1445122,0.000537519,0.0000393907,0.0001837679,0.004837803,0.0004928659,0.3214974,0.0004148526,0.5135581,0.001401878],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9614939,0.001394701,0.0005759327,0.0149699,0.001077269,0.0007250397,0.00002027473,0.0001533921,0.0195896],"genre_scores_gemma":[0.9828668,0.001158012,0.0001652228,0.01221108,0.0007456915,0.000107374,0.00003276314,0.00001918806,0.002693834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1534809,"threshold_uncertainty_score":0.6138387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06893165010882582,"score_gpt":0.3702827221498282,"score_spread":0.3013510720410023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}