{"id":"W2137059754","doi":"10.1007/s10875-004-6244-3","title":"CPG 7909, an Immunostimulatory TLR9 Agonist Oligodeoxynucleotide, as Adjuvant to Engerix-B� HBV Vaccine in Healthy Adults: A Double-Blind Phase I/II Study","year":2004,"lang":"en","type":"article","venue":"Journal of Clinical Immunology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":330,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network; Ottawa Hospital; Toronto Western Hospital; University of Ottawa","funders":"","keywords":"Medicine; HBsAg; Adjuvant; Immunogenicity; Tolerability; Immunology; CpG Oligodeoxynucleotide; Immune system; Adverse effect; Internal medicine; Hepatitis B virus; Biology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002239619,0.001939813,0.003810499,0.0006105356,0.0006964009,0.0007038446,0.001081219,0.002710062,0.002781594],"category_scores_gemma":[0.001066017,0.001110053,0.001159977,0.0004358941,0.002106502,0.001292448,0.0004192421,0.003357348,0.0008749928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004845855,"about_ca_system_score_gemma":0.001522986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006929021,"about_ca_topic_score_gemma":0.001304174,"domain_scores_codex":[0.9992022,0.0003597715,0.00006395502,0.0001310463,0.0000739898,0.0001690871],"domain_scores_gemma":[0.999155,0.0001858586,0.0001162456,0.00009047054,0.00007498626,0.0003773147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8810276,0.06856166,0.0005013394,0.0005700741,0.0003800576,0.00004865454,0.0000893394,0.0002700944,0.02746437,0.00007599568,0.0005036566,0.02050699],"study_design_scores_gemma":[0.5193254,0.4754668,0.001255047,0.00001588425,0.0002764885,0.00002945315,0.00002108816,0.0002000535,0.002892861,0.00006190777,0.0004389066,0.00001597177],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934999,0.00180869,0.0007209714,0.000257929,0.0002959476,0.002417858,0.0003317539,0.00007099519,0.0005958674],"genre_scores_gemma":[0.9845544,0.002628102,0.0025302,0.001127654,0.0005995919,0.004205294,0.0007290601,0.0000425641,0.003583179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003810499,"threshold_uncertainty_score":0.01184434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09171082531330603,"score_gpt":0.4688525420434794,"score_spread":0.3771417167301734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}