{"id":"W2137059754","doi":"10.1007/s10875-004-6244-3","title":"CPG 7909, an Immunostimulatory TLR9 Agonist Oligodeoxynucleotide, as Adjuvant to Engerix-B� HBV Vaccine in Healthy Adults: A Double-Blind Phase I/II Study","year":2004,"lang":"en","type":"article","venue":"Journal of Clinical Immunology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":330,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network; Ottawa Hospital; Toronto Western Hospital; University of Ottawa","funders":"","keywords":"Medicine; HBsAg; Adjuvant; Immunogenicity; Tolerability; Immunology; CpG Oligodeoxynucleotide; Immune system; Adverse effect; Internal medicine; Hepatitis B virus; Biology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003214817,0.0004856178,0.00288298,0.0007511844,0.0002694916,0.0000317424,0.0005929345,0.0004417632,0.0002456114],"category_scores_gemma":[0.003496472,0.0004031908,0.0004751066,0.0006411714,0.0002368078,0.0003628274,0.0003835276,0.002233357,0.0001882422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004229448,"about_ca_system_score_gemma":0.001349205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002589156,"about_ca_topic_score_gemma":0.00521458,"domain_scores_codex":[0.9922811,0.0006126281,0.00499211,0.0006412414,0.000628096,0.0008447749],"domain_scores_gemma":[0.9953885,0.0006711041,0.001379755,0.0009313439,0.0009580577,0.0006712017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6975518,0.06029449,0.1622902,0.00008821284,0.003463655,0.006979504,0.009262728,0.0002140786,0.002510462,0.0002392208,0.0004932953,0.05661229],"study_design_scores_gemma":[0.3183296,0.2420169,0.4263769,0.0007900336,0.0005861046,0.0009323655,0.001919671,0.00001840249,0.0003048314,0.0002406815,0.007992065,0.0004924569],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844184,0.003377449,0.00006117625,0.00851062,0.001810813,0.001582978,0.0000107954,0.00005255091,0.0001752362],"genre_scores_gemma":[0.9918538,0.002151455,0.001146665,0.003759702,0.0008825542,0.00005185002,0.000009183393,0.00007702771,0.00006770132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3792223,"threshold_uncertainty_score":0.999842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09171082531330603,"score_gpt":0.4688525420434794,"score_spread":0.3771417167301734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}