{"id":"W2137076228","doi":"10.1039/c2md20173a","title":"Two-in-one: a pH-sensitive, acridine-based, fluorescent probe binds G-quadruplexes in oncogene promoters","year":2012,"lang":"en","type":"article","venue":"MedChemComm","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kensington Health","funders":"","keywords":"Cyanine; Acridine; Fluorescence; G-quadruplex; Chemistry; Acridine derivatives; Promoter; Combinatorial chemistry; Biophysics; Biochemistry; Stereochemistry; Biology; DNA; Organic chemistry; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004737662,0.0007067752,0.0006160332,0.0002906562,0.0004255484,0.0006581537,0.001147509,0.001159475,0.002299703],"category_scores_gemma":[0.0007002535,0.0003921592,0.0003224943,0.0001941789,0.0005305831,0.001093469,0.0007224779,0.001417791,0.001448261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004315764,"about_ca_system_score_gemma":0.0003591993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001987597,"about_ca_topic_score_gemma":0.0003245494,"domain_scores_codex":[0.9994941,0.0001049375,0.00002849823,0.0001479863,0.000138074,0.00008643301],"domain_scores_gemma":[0.9995136,0.0001313277,0.00009764417,0.0000648331,0.00004910456,0.0001435929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001470748,0.00008828878,0.0001409726,0.000127871,0.000007911192,0.0001507058,0.00007558887,0.0002463518,0.9927371,0.0008678663,0.0002393588,0.005170808],"study_design_scores_gemma":[0.00001652077,0.0002307659,0.0001307516,0.000004385265,0.000006440398,0.0001938215,0.00001163808,0.00158745,0.9952019,0.0001197736,0.0024815,0.00001506591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8791404,0.001660153,0.1076997,0.001541522,0.0003479724,0.0003311474,0.0005517136,0.002458808,0.006268706],"genre_scores_gemma":[0.9302356,0.0007323459,0.05725234,0.0005421815,0.00005040047,0.0002464447,0.0005005699,0.0002641519,0.01017592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002299703,"threshold_uncertainty_score":0.007693231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01717460419864748,"score_gpt":0.2851727122096022,"score_spread":0.2679981080109547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}