{"id":"W2137081432","doi":"10.1046/j.1365-2958.2003.03673.x","title":"Cationic antimicrobial peptides activate a two‐component regulatory system, PmrA‐PmrB, that regulates resistance to polymyxin B and cationic antimicrobial peptides in <i>Pseudomonas aeruginosa</i>","year":2003,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":443,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Operon; Two-component regulatory system; Polymyxin; Response regulator; Biology; Antimicrobial peptides; Polymyxin B; Pseudomonas aeruginosa; Microbiology; Antimicrobial; Biochemistry; Mutant; Bacteria; Gene; Antibiotics; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000239298,0.0007026825,0.0003025704,0.0001681229,0.0001223057,0.0003881788,0.0001749769,0.0003040811,0.001158836],"category_scores_gemma":[0.00025585,0.0001931616,0.0003817941,0.00008816098,0.000258076,0.0002105837,0.0003971309,0.0005904467,0.0005643344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003549432,"about_ca_system_score_gemma":0.0002226738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005167974,"about_ca_topic_score_gemma":0.0003816328,"domain_scores_codex":[0.999661,0.0000755906,0.00002548626,0.00007004575,0.00007947774,0.00008839543],"domain_scores_gemma":[0.9997612,0.00006373451,0.00006871014,0.00002600571,0.00003350048,0.00004680872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002803142,0.000008365146,0.00007333361,0.000008325774,9.732901e-7,0.00000676022,0.000004472986,0.00001119272,0.9995558,0.00001500473,0.00001071689,0.0002771358],"study_design_scores_gemma":[0.00002272969,0.0002108539,0.006983234,0.000005954339,0.00001124917,0.0002088289,0.0000277882,0.0008882853,0.9908288,0.0000405002,0.000763321,0.000008523456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911901,0.0009578842,0.006226806,0.0001456138,0.00003372109,0.00006114574,0.0003222208,0.0001837919,0.0008787404],"genre_scores_gemma":[0.99228,0.0002582509,0.004939673,0.0001109007,0.00001452756,0.00007291807,0.0006535876,0.0000388018,0.001631347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001158836,"threshold_uncertainty_score":0.003876686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006586168493656967,"score_gpt":0.2052590217536653,"score_spread":0.1986728532600084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}