{"id":"W2137081432","doi":"10.1046/j.1365-2958.2003.03673.x","title":"Cationic antimicrobial peptides activate a two‐component regulatory system, PmrA‐PmrB, that regulates resistance to polymyxin B and cationic antimicrobial peptides in <i>Pseudomonas aeruginosa</i>","year":2003,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":443,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Operon; Two-component regulatory system; Polymyxin; Response regulator; Biology; Antimicrobial peptides; Polymyxin B; Pseudomonas aeruginosa; Microbiology; Antimicrobial; Biochemistry; Mutant; Bacteria; Gene; Antibiotics; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007517263,0.0009290366,0.001269381,0.0006908733,0.0006249839,0.0001427131,0.0006203455,0.0007078716,0.00005682059],"category_scores_gemma":[0.0001049416,0.0009734043,0.000311084,0.0005602213,0.001005737,0.0003041355,0.0003375952,0.0007279249,0.0002877096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004492023,"about_ca_system_score_gemma":0.0003073894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006630791,"about_ca_topic_score_gemma":0.0008617264,"domain_scores_codex":[0.9945473,0.001145449,0.00105817,0.00161467,0.00007525081,0.001559181],"domain_scores_gemma":[0.997947,0.0002217002,0.0005109845,0.001011382,0.0001746516,0.0001342808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000370203,0.0002314233,0.002239274,0.0002091168,0.0002368715,0.00007224192,0.0005681606,0.0001810783,0.9831182,0.006427809,0.006215295,0.0001303091],"study_design_scores_gemma":[0.002931546,0.0001229971,0.002250191,0.0005905377,0.0001058785,0.001278691,0.0003650681,0.000002041912,0.9762162,0.0001161952,0.01493703,0.001083624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922708,0.002464935,0.0003940195,0.001101731,0.0009112486,0.001248175,0.0002249852,0.0002244361,0.001159619],"genre_scores_gemma":[0.9938085,0.0001470939,0.001630341,0.001363612,0.00005608189,0.00008404401,0.0004253401,0.00012905,0.002355946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00872174,"threshold_uncertainty_score":0.9992716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006586168493656967,"score_gpt":0.2052590217536653,"score_spread":0.1986728532600084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}