{"id":"W2137108719","doi":"10.1074/jbc.m100728200","title":"Inhibition of the G2 DNA Damage Checkpoint and of Protein Kinases Chk1 and Chk2 by the Marine Sponge Alkaloid Debromohymenialdisine","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of British Columbia","funders":"","keywords":"G2-M DNA damage checkpoint; CHEK1; DNA damage; Cell cycle checkpoint; Checkpoint Kinase 2; Kinase; DNA repair; Cell cycle; DNA-PKcs; Cell biology; Biology; DNA; Cancer research; Molecular biology; Biochemistry; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000565794,0.0004959416,0.0002320291,0.0001370279,0.0001165337,0.0001686597,0.0001235541,0.0002297837,0.001448809],"category_scores_gemma":[0.00008773503,0.00009235814,0.0001995445,0.00009913855,0.0001587529,0.0001683663,0.0001617201,0.000314653,0.0004028474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002686255,"about_ca_system_score_gemma":0.0002306778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005068477,"about_ca_topic_score_gemma":0.001231231,"domain_scores_codex":[0.9999493,0.000008568656,0.000004824371,0.00001178218,0.00001227265,0.00001326713],"domain_scores_gemma":[0.9999369,0.00001538555,0.00001672854,0.000006882844,0.000005590677,0.00001846715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000141284,0.000009149857,0.0001440603,0.00008435898,0.000005619731,0.00002427056,0.000004994552,0.00006886914,0.9981269,0.00003574073,0.00002362124,0.001331208],"study_design_scores_gemma":[0.00003009383,0.000386728,0.004896938,0.000006174437,0.00001244115,0.0002411168,0.00001358662,0.0002651,0.9917597,0.00002720545,0.002356351,0.000004631369],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837776,0.009809763,0.002187785,0.0001193222,0.00003215109,0.00005534112,0.0008748742,0.00008653163,0.003056686],"genre_scores_gemma":[0.9913833,0.00315909,0.001885524,0.00004003136,0.000008565688,0.00003775518,0.000887112,0.00001427512,0.002584437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001448809,"threshold_uncertainty_score":0.004846752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009000278784963612,"score_gpt":0.2144047570933404,"score_spread":0.2054044783083767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}