{"id":"W2137130674","doi":"10.1158/1078-0432.ccr-04-2159","title":"Inhibition of Heme Oxygenase-1 Increases Responsiveness of Pancreatic Cancer Cells to Anticancer Treatment","year":2005,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":264,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pancreas Centre (Canada)","funders":"","keywords":"Pancreatic cancer; Heme oxygenase; Cancer cell; Cancer research; Cancer; Gemcitabine; Transfection; Pancreas; Chemotherapy; Gene knockdown; Cell growth; Cell culture; Biology; Internal medicine; Medicine; Endocrinology; Heme; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001323456,0.0002448404,0.0005060119,0.0002256492,0.0001153301,0.000276603,0.0001740126,0.0002347127,0.001467972],"category_scores_gemma":[0.0001810614,0.0001285773,0.0002410449,0.000253231,0.0001304578,0.0001251267,0.0001866026,0.0007317181,0.0003633267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002047356,"about_ca_system_score_gemma":0.0001867078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000401416,"about_ca_topic_score_gemma":0.0004330975,"domain_scores_codex":[0.9998293,0.00003454714,0.00001679714,0.00003379719,0.00004172402,0.00004385494],"domain_scores_gemma":[0.9998674,0.00004772195,0.00002459155,0.00001841209,0.00001539101,0.00002653876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003833506,0.0002095829,0.0002525219,0.00007917814,0.0000127346,0.00005383233,0.00003333007,0.0001451632,0.9947337,0.00004557524,0.0002513161,0.003799714],"study_design_scores_gemma":[0.000044978,0.001467968,0.008858511,0.00001159785,0.0000279493,0.0002380875,0.00003608973,0.001803928,0.9830446,0.00003917821,0.004419186,0.000007983581],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906826,0.004737477,0.001423836,0.0001970869,0.00009356435,0.0000583386,0.0004321428,0.0002020832,0.00217281],"genre_scores_gemma":[0.9930906,0.002260307,0.001273776,0.00009729224,0.00002068607,0.00008046364,0.0009462205,0.0000205153,0.002210035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001467972,"threshold_uncertainty_score":0.004910886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1061858291135664,"score_gpt":0.4645964321959659,"score_spread":0.3584106030823995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}