{"id":"W2137135936","doi":"10.1038/nrneurol.2013.129","title":"New treatments for mitochondrial disease—no time to drop our standards","year":2013,"lang":"en","type":"review","venue":"Nature Reviews Neurology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":170,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute for Health and Care Research; Canadian Institutes of Health Research; National Institute of Neurological Disorders and Stroke; Medical Research Council; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust","keywords":"Medicine; Mitochondrial disease; Disease; Intensive care medicine; Clinical trial; MEDLINE; Multisystem disease; Biomarker; Clinical study design; Bioinformatics; Mitochondrial DNA; Pathology; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001743975,0.001218817,0.002153363,0.001757502,0.0005145143,0.001299942,0.001496011,0.002627881,0.005107299],"category_scores_gemma":[0.002119966,0.0003520117,0.0005596898,0.001399978,0.001549452,0.003161936,0.001210311,0.006096756,0.003017413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001037861,"about_ca_system_score_gemma":0.001407364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001151887,"about_ca_topic_score_gemma":0.003346275,"domain_scores_codex":[0.9996093,0.00008822789,0.00004993069,0.00004691494,0.0001630867,0.00004250709],"domain_scores_gemma":[0.9989098,0.0005869932,0.00009252431,0.00003863913,0.0002610743,0.0001109508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001385753,0.00008152254,0.00009330467,0.007693028,0.00009193629,0.0002277054,0.00004737604,0.0002933734,0.001190203,0.009381518,0.1802205,0.800541],"study_design_scores_gemma":[0.00003925926,0.00006086877,0.0002158162,0.002039495,0.00005568432,0.000483366,0.00003739966,0.00005685216,0.0001466856,0.005764113,0.9910818,0.00001853976],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003479468,0.9956214,0.0002004548,0.002109867,0.001229593,0.000003622637,0.00001421384,0.00001364296,0.0007723231],"genre_scores_gemma":[0.000484829,0.9942328,0.0003746985,0.002341195,0.001701552,0.000008935371,0.00002804212,0.000005046814,0.0008229082],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005107299,"threshold_uncertainty_score":0.01708567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02156267863059702,"score_gpt":0.3460823559627938,"score_spread":0.3245196773321968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}