{"id":"W2137163300","doi":"10.1210/mend.14.12.0565","title":"Receptor/β-Arrestin Complex Formation and the Differential Trafficking and Resensitization ofβ<sub>2</sub>-Adrenergic and Angiotensin II Type 1A Receptors","year":2000,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Internalization; Endocytic cycle; Cell biology; Biology; Receptor; Dynamin; Arrestin; G protein-coupled receptor; Endosome; Endocytosis; Signal transduction; Intracellular; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000113822,0.0002117764,0.0002329711,0.0000635124,0.0003073499,0.00005132792,0.00008022293,0.0001526877,0.00005430334],"category_scores_gemma":[0.00004387695,0.0001757965,0.00004935377,0.00009537453,0.0002668115,0.00001046445,0.0001271343,0.0001291061,0.000003136803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009243033,"about_ca_system_score_gemma":0.00001477271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002413834,"about_ca_topic_score_gemma":0.00002149094,"domain_scores_codex":[0.9986812,0.0002419695,0.0002464811,0.0003937964,0.0001129945,0.0003235932],"domain_scores_gemma":[0.9995464,0.00002350603,0.000080477,0.0002011458,0.00007237186,0.00007609501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003669354,0.00001455721,0.00002442189,0.000009674934,0.00004313685,0.000007163559,0.0001987053,0.0001926053,0.9562635,0.000889427,0.0002960481,0.04169381],"study_design_scores_gemma":[0.002318747,0.0005323208,0.0004257404,0.00002351812,0.00006896548,0.0003498679,0.0001239091,0.005317232,0.9789767,0.0003681691,0.01116053,0.000334365],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955051,0.001522374,0.001867712,0.0005645795,0.0001620888,0.0002406601,0.000004267833,0.00002684811,0.0001063967],"genre_scores_gemma":[0.9963773,0.002301966,0.0006254283,0.00030387,0.0001157198,0.0000102785,0.0001926381,0.00002820011,0.00004461655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04135945,"threshold_uncertainty_score":0.7168772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00869912186092356,"score_gpt":0.210779337097663,"score_spread":0.2020802152367394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}