{"id":"W2137167442","doi":"10.1001/jama.296.2.185","title":"Salpingo-oophorectomy and the Risk of Ovarian, Fallopian Tube, and Peritoneal Cancers in Women With a <EMPH TYPE=\"ITAL\">BRCA1</EMPH> or <EMPH TYPE=\"ITAL\">BRCA2</EMPH> Mutation","year":2006,"lang":"en","type":"article","venue":"JAMA","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":600,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"National Cancer Institute","keywords":"Medicine; Ovarian cancer; Fallopian tube; Fallopian tube cancer; Gynecology; Incidence (geometry); BRCA mutation; Oophorectomy; Cohort; Obstetrics; Cancer; Internal medicine; Surgery; Hysterectomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008004833,0.0006057482,0.0006836302,0.0002490615,0.0002849484,0.0001962419,0.0004488746,0.0005275461,0.0001008883],"category_scores_gemma":[0.0002906696,0.0004709017,0.0001086018,0.0008987566,0.0008235594,0.00006299037,0.0002536083,0.0003495128,0.00001283336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000532398,"about_ca_system_score_gemma":0.001127058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001179153,"about_ca_topic_score_gemma":0.006613384,"domain_scores_codex":[0.9965239,0.0003312916,0.0007782134,0.001074266,0.0005152461,0.0007771529],"domain_scores_gemma":[0.9978595,0.0001589448,0.0004659806,0.0008276121,0.0004899037,0.0001980349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.03090188,0.001176719,0.05983345,0.001272678,0.003878978,0.0004188078,0.01850518,0.01060615,0.7462379,0.005098918,0.04028963,0.08177976],"study_design_scores_gemma":[0.05893252,0.006696621,0.3791999,0.0008895044,0.001196707,0.001171873,0.004620629,0.00835525,0.1115295,0.002799744,0.4195323,0.005075458],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893214,0.005176006,0.0002110553,0.0007174798,0.000441724,0.0009855105,0.0002218693,0.00004796441,0.002877031],"genre_scores_gemma":[0.993302,0.001394193,0.002105329,0.0004272505,0.0006576897,0.0002522036,0.0002405896,0.0001259231,0.001494838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6347084,"threshold_uncertainty_score":0.9997743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005444280922161365,"score_gpt":0.2254252789419174,"score_spread":0.219980998019756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}