{"id":"W2137167442","doi":"10.1001/jama.296.2.185","title":"Salpingo-oophorectomy and the Risk of Ovarian, Fallopian Tube, and Peritoneal Cancers in Women With a <EMPH TYPE=\"ITAL\">BRCA1</EMPH> or <EMPH TYPE=\"ITAL\">BRCA2</EMPH> Mutation","year":2006,"lang":"en","type":"article","venue":"JAMA","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":600,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"National Cancer Institute","keywords":"Medicine; Ovarian cancer; Fallopian tube; Fallopian tube cancer; Gynecology; Incidence (geometry); BRCA mutation; Oophorectomy; Cohort; Obstetrics; Cancer; Internal medicine; Surgery; Hysterectomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003456102,0.0001558358,0.0001741586,0.0003572137,0.0001526221,0.0001915756,0.0001839576,0.0003164954,0.0007050366],"category_scores_gemma":[0.001557064,0.0001716982,0.0002889754,0.0004280805,0.0001790123,0.0001395836,0.0001605308,0.0002741641,0.00005481071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003057063,"about_ca_system_score_gemma":0.000343165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007852441,"about_ca_topic_score_gemma":0.0110346,"domain_scores_codex":[0.9998741,0.0000401748,0.000009219799,0.00002580335,0.00002638816,0.00002439177],"domain_scores_gemma":[0.9993846,0.0001271504,0.0003314698,0.00003208666,0.00002781847,0.00009682339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004144219,0.00003097652,0.9982538,0.000007606659,0.00002577394,0.00002386939,0.00002004824,0.00003242852,0.00008869815,0.000005489981,0.00003816607,0.001058855],"study_design_scores_gemma":[0.00003009279,0.0001805426,0.9992751,0.00000530824,0.00003700139,0.000167166,0.00004148064,0.0001303641,0.00004313789,0.0000116967,0.0000768854,0.000001283326],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999441,0.0002969531,0.00001635081,0.00002550073,0.00000217852,0.000003518508,0.00009948059,0.000001048291,0.0001139907],"genre_scores_gemma":[0.9995916,0.0001695999,0.00003404794,0.00001232608,0.00000453005,0.000004179061,0.0001149845,3.255964e-7,0.00006830235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007852441,"threshold_uncertainty_score":0.01561344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005444280922161365,"score_gpt":0.2254252789419174,"score_spread":0.219980998019756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}