{"id":"W2137177799","doi":"10.1074/jbc.m210785200","title":"An NS3 Serine Protease Inhibitor Abrogates Replication of Subgenomic Hepatitis C Virus RNA","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Subgenomic mRNA; NS3; Virology; Serine protease; NS2-3 protease; Hepatitis C virus; Chemistry; MASP1; Protease inhibitor (pharmacology); RNA; Viral replication; Protease; Virus; Biology; Enzyme; Biochemistry; Viral load; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001681091,0.0004388365,0.0004270172,0.0001994148,0.0001452781,0.0002662762,0.0002497118,0.0002270579,0.00117492],"category_scores_gemma":[0.0001870736,0.0001621048,0.0002237656,0.0001374731,0.0002009329,0.0001477795,0.0001150759,0.0005325355,0.0003762858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002705398,"about_ca_system_score_gemma":0.0002877476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001017507,"about_ca_topic_score_gemma":0.001675685,"domain_scores_codex":[0.9998374,0.00003382262,0.00001645917,0.00001768467,0.00003987742,0.00005465473],"domain_scores_gemma":[0.9998637,0.0000471132,0.00002330325,0.00001823062,0.00001637124,0.0000312267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005831545,0.0002267228,0.0001226741,0.00004049423,0.00001185,0.00003973923,0.00001430028,0.0001724989,0.9951295,0.00009427249,0.00008702813,0.003477769],"study_design_scores_gemma":[0.00005584707,0.001609737,0.001682327,0.000003376371,0.00001681039,0.0001304683,0.000009146942,0.001041256,0.9944745,0.00002190624,0.0009506219,0.000004012259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957213,0.001129122,0.001083227,0.00004959884,0.00004440968,0.00004070294,0.0002383864,0.0000736638,0.001619561],"genre_scores_gemma":[0.9941719,0.001090859,0.001196953,0.0000425433,0.00002265222,0.00003874926,0.0006080784,0.00002986235,0.002798528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00117492,"threshold_uncertainty_score":0.003930509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03790442252034686,"score_gpt":0.3292866034433141,"score_spread":0.2913821809229672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}