{"id":"W2137216847","doi":"10.1128/iai.70.8.4068-4074.2002","title":"Lipopolysaccharide-Binding Protein- and CD14-Dependent Activation of Mitogen-Activated Protein Kinase p38 by Lipopolysaccharide in Human Neutrophils Is Associated with Priming of Respiratory Burst","year":2002,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"IWK Health Centre; Medical Research Council Canada","keywords":"Respiratory burst; Lipopolysaccharide; CD14; Biology; Priming (agriculture); p38 mitogen-activated protein kinases; Protein kinase A; TLR4; Lipopolysaccharide binding protein; Mitogen-activated protein kinase; Cell biology; Immunology; Kinase; Signal transduction; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002094573,0.000383632,0.0001904604,0.0001960301,0.0001432433,0.0001674275,0.0001260856,0.0002659053,0.001705787],"category_scores_gemma":[0.0001767962,0.0001644683,0.0003051336,0.0001308939,0.0001643396,0.000169745,0.000232511,0.0003891468,0.0005179632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001859938,"about_ca_system_score_gemma":0.0001521982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002145501,"about_ca_topic_score_gemma":0.0002617333,"domain_scores_codex":[0.9998094,0.00005416297,0.00002189338,0.00003125352,0.00003757263,0.00004573843],"domain_scores_gemma":[0.9999254,0.00001071816,0.00002165573,0.00001262587,0.000008858258,0.00002078199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003633,0.00004396154,0.0002519983,0.00003898582,0.000003015791,0.0001116529,0.00001658774,0.0000147487,0.9985151,0.00003649325,0.00001729423,0.0005869261],"study_design_scores_gemma":[0.000103888,0.0008406641,0.02329005,0.00001314988,0.00001665709,0.0009474819,0.00003965697,0.0009061834,0.9723474,0.00009115072,0.001398038,0.000005693742],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960675,0.001351678,0.001478941,0.0000634698,0.00001927123,0.00008465307,0.0002666306,0.00002299548,0.0006447057],"genre_scores_gemma":[0.9950988,0.000687421,0.002345289,0.00003544771,0.00001300468,0.0001404602,0.0006837441,0.000005191338,0.000990542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001705787,"threshold_uncertainty_score":0.005706429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02587145527632892,"score_gpt":0.2397843362032279,"score_spread":0.2139128809268989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}