{"id":"W2137229556","doi":"10.1152/ajpheart.01344.2005","title":"Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulin","year":2006,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute","keywords":"Gene isoform; Internal medicine; Peroxisome; Endocrinology; Biology; Insulin; Thioesterase; Insulin receptor; Peroxisome proliferator-activated receptor; Cytosol; Receptor; Biochemistry; Enzyme; Gene; Insulin resistance; Biosynthesis; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001750276,0.0002487606,0.0002008838,0.0004042994,0.00009120549,0.0002470976,0.0001598014,0.0001643026,0.0005823453],"category_scores_gemma":[0.0001380756,0.0002630363,0.0003490717,0.0001457363,0.0003494674,0.0001917362,0.0001855673,0.0003881601,0.0001843673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002241875,"about_ca_system_score_gemma":0.0001264968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003806177,"about_ca_topic_score_gemma":0.0006735483,"domain_scores_codex":[0.9998596,0.00001349423,0.00001062813,0.00006292349,0.00002245953,0.00003103277],"domain_scores_gemma":[0.9997976,0.00002196224,0.00007474295,0.00002058672,0.00002195141,0.00006318006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003517627,0.00002182812,0.001731104,0.00002162976,0.000007805667,0.00004675224,0.0000301445,0.00002631661,0.996445,0.00009884207,0.0000214649,0.001197369],"study_design_scores_gemma":[0.0001503003,0.001033238,0.2191139,0.00001777341,0.0001294931,0.0006326017,0.0002642359,0.001174183,0.7752011,0.0002563843,0.002000608,0.00002619955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962978,0.001443821,0.001290526,0.0000646784,0.00001501854,0.000009609535,0.0002620018,0.00004220291,0.0005744346],"genre_scores_gemma":[0.9941406,0.0007979284,0.001951444,0.00009899982,0.00001568267,0.00004019461,0.0006553784,0.00002245569,0.002277377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005823453,"threshold_uncertainty_score":0.001948118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005886573171175362,"score_gpt":0.2215531176186812,"score_spread":0.2156665444475058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}