{"id":"W2137230390","doi":"10.1182/blood-2005-05-2096","title":"Enhanced TNF-α–induced apoptosis in Fanconi anemia type C–deficient cells is dependent on apoptosis signal-regulating kinase 1","year":2005,"lang":"en","type":"article","venue":"Blood","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; University of Toronto; Hospital for Sick Children; Riley Children's Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; University of Missouri; Fanconi Anemia Research Fund","keywords":"Apoptosis; Fanconi anemia; Cancer research; Anemia; Kinase; Signal transduction; Tumor necrosis factor alpha; Medicine; Biology; Cell biology; Immunology; Internal medicine; DNA; Genetics; DNA repair","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002172637,0.0002901476,0.0002380921,0.0001020081,0.00007609108,0.00003712906,0.0002655774,0.0002767103,0.0001367795],"category_scores_gemma":[0.00003867983,0.0003005829,0.0001207136,0.0001864829,0.00002192808,0.00000659578,0.0001380993,0.0001670507,0.0001197937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005058702,"about_ca_system_score_gemma":0.00007244711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003441095,"about_ca_topic_score_gemma":0.00003861474,"domain_scores_codex":[0.998099,0.00007391338,0.0003575422,0.0006947609,0.0002917611,0.0004829797],"domain_scores_gemma":[0.9990795,0.00001903551,0.0001337112,0.00057012,0.00007353322,0.0001241263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006574301,0.0005575001,0.00006381675,0.00001901234,0.00003376461,0.000001595474,0.0001525803,0.0004270345,0.9941007,0.00002229629,0.0001287309,0.00442724],"study_design_scores_gemma":[0.001519937,0.0005736335,0.00006367701,0.00004676006,0.00004319199,0.000002738015,0.0001224737,0.0001072233,0.9968272,0.00001515859,0.0003259991,0.0003520392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996932,0.0001305477,0.0002059116,0.0000844262,0.000188757,0.0003227499,0.00001432114,0.00003834899,0.002082978],"genre_scores_gemma":[0.9962534,0.00003567094,0.002316492,0.0005331836,0.0002120971,0.00004628989,0.00003516862,0.00004985102,0.0005178584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004075201,"threshold_uncertainty_score":0.9999446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01046687994269755,"score_gpt":0.2369853487684326,"score_spread":0.2265184688257351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}