{"id":"W2137232836","doi":"10.1021/cb500499x","title":"RNA Mango Aptamer-Fluorophore: A Bright, High-Affinity Complex for RNA Labeling and Tracking","year":2014,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":453,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"RNA; Aptamer; Fluorophore; Fluorescence; Biophysics; Chemistry; Biochemistry; Biology; Molecular biology; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000295201,0.0002137984,0.0003025286,0.00002676345,0.0001056752,0.0000228072,0.0002433337,0.0003840108,0.00002601186],"category_scores_gemma":[0.0003416233,0.0001865463,0.00008589752,0.00004486874,0.0001633582,0.00000339721,0.000146554,0.000102374,0.000008558403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008879912,"about_ca_system_score_gemma":0.00001663622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002504919,"about_ca_topic_score_gemma":0.000003911602,"domain_scores_codex":[0.9987054,0.00008773126,0.0002551454,0.0005197966,0.00005374625,0.0003781762],"domain_scores_gemma":[0.9992803,0.0001294312,0.0001050668,0.0003015308,0.0000715997,0.000112063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001072665,0.00002928618,0.00009034102,0.00002205277,0.00004053234,3.901103e-7,0.00001152835,3.576108e-7,0.9461718,0.002749855,0.0003209222,0.0504557],"study_design_scores_gemma":[0.0006856793,0.0002343629,0.0001161305,0.000009925315,0.00002579002,0.00001115036,0.000006996351,0.00003664179,0.961727,0.006184883,0.03071094,0.0002504872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884177,0.0004167786,0.009950306,0.0004549101,0.0001279186,0.00025227,0.00004187995,0.00002828637,0.00030992],"genre_scores_gemma":[0.9854538,0.0001374791,0.01270869,0.0008175381,0.0004863965,0.00006221535,0.0002488911,0.00002951008,0.00005547072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05020521,"threshold_uncertainty_score":0.7607137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02080928313015288,"score_gpt":0.2576458321678973,"score_spread":0.2368365490377444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}