{"id":"W2137268781","doi":"10.1158/1535-7163.mct-09-0960","title":"Potent Preclinical Impact of Metronomic Low-Dose Oral Topotecan Combined with the Antiangiogenic Drug Pazopanib for the Treatment of Ovarian Cancer","year":2010,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"GlaxoSmithKline (Canada); Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"National Cancer Institute; Canada Research Chairs; GlaxoSmithKline","keywords":"Topotecan; Medicine; Pazopanib; Ovarian cancer; Pharmacology; Paclitaxel; Irinotecan; Chemotherapy; Cyclophosphamide; Ovarian carcinoma; Cancer; Oncology; Internal medicine; Sunitinib; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001847521,0.0003074832,0.0005926796,0.00005443079,0.00009901575,0.00002039596,0.0002223767,0.00009263603,0.0001475323],"category_scores_gemma":[0.00000447057,0.0001444033,0.0006789199,0.0002161137,0.0002770405,0.00002450362,0.0000199836,0.000150047,8.78189e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003422266,"about_ca_system_score_gemma":0.0008044917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003554794,"about_ca_topic_score_gemma":0.002282975,"domain_scores_codex":[0.9986321,0.00006468112,0.0003750177,0.000328057,0.0002608541,0.0003393068],"domain_scores_gemma":[0.9983798,0.0002086804,0.0002862392,0.0008256201,0.0001959209,0.000103687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.02075608,0.01005561,0.2057691,0.0002756833,0.05035168,0.0000571768,0.004490484,0.006080492,0.1306809,0.001673764,0.0006726686,0.5691364],"study_design_scores_gemma":[0.03668548,0.0157776,0.5422763,0.0002585466,0.01619941,0.00002424104,0.0003151312,0.004667925,0.364939,0.0002334338,0.01793488,0.0006880006],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794526,0.008053376,0.0005244734,0.009130679,0.0003209861,0.002222906,0.0002467112,0.00001714293,0.00003110554],"genre_scores_gemma":[0.9956879,0.002273137,0.000500494,0.000483734,0.0001418971,0.0007339494,0.00002006087,0.0000626979,0.0000961152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5684484,"threshold_uncertainty_score":0.5888597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03021178287455396,"score_gpt":0.3444115221306979,"score_spread":0.314199739256144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}