{"id":"W2137283728","doi":"10.1128/mcb.21.7.2384-2392.2001","title":"Establishment and Maintenance of DNA Methylation Patterns in Mouse <i>Ndn</i> : Implications for Maintenance of Imprinting in Target Genes of the Imprinting Center","year":2001,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Division of Materials Research","keywords":"Genomic imprinting; Biology; Imprinting (psychology); DNA methylation; Epigenetics; Genetics; Blastocyst; Methylation; Gene; CpG site; Bisulfite sequencing; DNA demethylation; Oocyte; RNA-Directed DNA Methylation; Molecular biology; Embryo; Embryogenesis; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003405513,0.0001241348,0.0002352612,0.00006597748,0.00002442005,0.000004653907,0.0001496126,0.0001143738,0.000001473981],"category_scores_gemma":[0.0000863131,0.0001028907,0.00008068151,0.000104083,0.0001069341,0.000003717272,0.0002163888,0.00005899275,2.640409e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000728995,"about_ca_system_score_gemma":0.00002031014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001242927,"about_ca_topic_score_gemma":0.00005810092,"domain_scores_codex":[0.9988934,0.00007806292,0.0004452925,0.0003004437,0.00003894588,0.0002438477],"domain_scores_gemma":[0.9993607,0.00001962388,0.0002470636,0.0002693364,0.00007683972,0.00002646184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008013676,0.00002540483,0.3655865,0.00004792306,0.00001155761,1.574793e-7,0.000034656,0.00004504364,0.630209,0.000189902,6.056769e-7,0.003841204],"study_design_scores_gemma":[0.0007562472,0.0001167866,0.1189888,0.00004130586,0.000008018511,0.00001047844,0.0001360905,0.0002011797,0.87899,0.0003565905,0.0002971767,0.00009737552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9664356,0.0008927139,0.0320833,0.0001361969,0.00003645819,0.0003314867,0.00003309869,0.00000153607,0.00004964065],"genre_scores_gemma":[0.9978191,0.0003072511,0.001731872,0.00003862647,0.00001023785,0.00002891094,0.00003046907,0.00001310975,0.00002043455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.248781,"threshold_uncertainty_score":0.4195761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007802827356174907,"score_gpt":0.2299571349854685,"score_spread":0.2221543076292936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}