{"id":"W2137289976","doi":"10.1074/jbc.m110.148361","title":"Bcl-2 and Bax Interact via the BH1–3 Groove-BH3 Motif Interface and a Novel Interface Involving the BH4 Motif","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Bcl-2-associated X protein; Biophysics; Biology; Chemistry; Crystallography; Molecular biology; Cell biology; Apoptosis; Biochemistry; Programmed cell death; Caspase 3","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000501971,0.0002355087,0.000248096,0.00001596702,0.0001268878,0.0001085828,0.0005690348,0.0002841343,0.00006684187],"category_scores_gemma":[0.0004077031,0.0001163127,0.0001385864,0.00005415752,0.0004275371,0.00001531349,0.0004530492,0.0007976724,0.000002826945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001093402,"about_ca_system_score_gemma":0.00003437098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001096732,"about_ca_topic_score_gemma":0.00001199675,"domain_scores_codex":[0.9988669,0.00004976026,0.0004299774,0.0002893119,0.0001222441,0.0002418464],"domain_scores_gemma":[0.9989724,0.0001190989,0.0003189874,0.0003048916,0.0001599166,0.0001247387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001495528,0.00005975436,0.003188086,0.00001591292,0.00008462368,0.000004446373,0.00009859209,0.000006921887,0.9936255,0.000006053778,0.0005503728,0.002210196],"study_design_scores_gemma":[0.0005229526,0.0004570677,0.007481738,0.00007157966,0.00003749358,0.00131912,0.0007295226,0.0002583204,0.9822547,0.0002541837,0.006384329,0.000228995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933848,0.00319808,0.001825856,0.0009930442,0.000266328,0.00007890676,0.00001025791,0.000005271575,0.0002374177],"genre_scores_gemma":[0.9978766,0.0007572562,0.0002248397,0.0003444713,0.0005172077,0.000003449136,0.000004481983,0.00001192599,0.0002597003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01137079,"threshold_uncertainty_score":0.4743093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01591083557955999,"score_gpt":0.2581823196622061,"score_spread":0.2422714840826461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}