{"id":"W2137310532","doi":"10.1371/journal.pone.0058504","title":"The Systemic Cytokine Environment Is Permanently Altered in Multiple Myeloma","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Indiana Clinical and Translational Sciences Institute; Canadian Institutes of Health Research; National Institutes of Health; University of Alberta; National Center for Advancing Translational Sciences; Purdue University","keywords":"Cytokine; Monoclonal gammopathy of undetermined significance; Multiple myeloma; Malignancy; Medicine; Interleukin 6; Immunology; Bone marrow; Monoclonal; Internal medicine; Monoclonal antibody; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001244144,0.000158638,0.0002798707,0.00007462165,0.0001193993,0.0000369334,0.0001370791,0.00005928931,0.0008346916],"category_scores_gemma":[0.00009970884,0.0001018995,0.00005962007,0.00008320605,0.00007632237,0.00007465899,0.00008254885,0.0001998627,0.002968286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002258047,"about_ca_system_score_gemma":0.00003105685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003412691,"about_ca_topic_score_gemma":0.00002625096,"domain_scores_codex":[0.9983096,0.00007092402,0.000282805,0.0002709706,0.0006020741,0.000463689],"domain_scores_gemma":[0.9990147,0.0001589422,0.00005366084,0.0005098046,0.00004171065,0.0002211899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003940918,0.003608797,0.587526,0.0003322212,0.0008123189,0.0001372296,0.0007424593,0.000001162811,0.3964339,0.00001723895,0.001025709,0.00896882],"study_design_scores_gemma":[0.00900522,0.0006276065,0.8285998,0.0007461634,0.0001463347,0.00005409431,0.0004126618,0.01213548,0.1472585,0.00006678735,0.0006884812,0.0002589289],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994185,0.0007614566,0.000004101588,0.002441266,0.00001806241,0.001701086,0.00002069691,0.00003361226,0.000834755],"genre_scores_gemma":[0.9952956,0.000748775,0.0003893243,0.0001745967,0.0001089786,0.0005580986,0.00004332215,0.00002706363,0.002654194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2491754,"threshold_uncertainty_score":0.997808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0526773085017002,"score_gpt":0.2477584192903351,"score_spread":0.1950811107886349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}