{"id":"W2137324425","doi":"10.1080/10799890600923161","title":"Synthesis of an Agonistic, Difluoro-Azido Photolabel of Angiotensin II and Labeling of the AT<sub>1</sub>Receptor: Transmembrane Domains 3, 6, and 7 Form the Ligand-Binding Pocket","year":2006,"lang":"en","type":"article","venue":"Journal of Receptors and Signal Transduction","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Photoaffinity labeling; Transmembrane domain; Radioligand; Agonist; Receptor; Stereochemistry; Transmembrane protein; Nitrene; Combinatorial chemistry; Biophysics; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001598381,0.0003322652,0.000231223,0.0001245425,0.0001589915,0.0001493989,0.0002892634,0.0004008238,0.0008684104],"category_scores_gemma":[0.0001242351,0.0001656807,0.0002118518,0.0001238766,0.0001557875,0.0001545964,0.0001588751,0.0004877837,0.0004366031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003177005,"about_ca_system_score_gemma":0.0002909304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005899654,"about_ca_topic_score_gemma":0.001016973,"domain_scores_codex":[0.9999118,0.00001525024,0.000005261905,0.00002542253,0.00001935266,0.00002293366],"domain_scores_gemma":[0.9999011,0.00002087285,0.00002139981,0.00001150829,0.00001421717,0.00003093318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002960853,0.000008682814,0.00003688385,0.00001704805,0.000002319195,0.00004010973,0.000007557159,0.00004313714,0.9991177,0.000059496,0.0000118317,0.0006257584],"study_design_scores_gemma":[0.00001104236,0.0001528253,0.0005623946,0.000001569052,0.000009113816,0.0002341247,0.000004768193,0.0001911388,0.9974481,0.00001741782,0.00136392,0.000003457041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9739353,0.001083631,0.02173644,0.00009515227,0.00004338867,0.0001388931,0.0004046381,0.00008953839,0.002473082],"genre_scores_gemma":[0.9600433,0.0009471609,0.03416556,0.00009316885,0.00001957238,0.0001108035,0.000761166,0.00003622175,0.003822986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008684104,"threshold_uncertainty_score":0.00290513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005296678289089595,"score_gpt":0.1957606336278905,"score_spread":0.1904639553388009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}