{"id":"W2137324425","doi":"10.1080/10799890600923161","title":"Synthesis of an Agonistic, Difluoro-Azido Photolabel of Angiotensin II and Labeling of the AT<sub>1</sub>Receptor: Transmembrane Domains 3, 6, and 7 Form the Ligand-Binding Pocket","year":2006,"lang":"en","type":"article","venue":"Journal of Receptors and Signal Transduction","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Photoaffinity labeling; Transmembrane domain; Radioligand; Agonist; Receptor; Stereochemistry; Transmembrane protein; Nitrene; Combinatorial chemistry; Biophysics; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006995929,0.0001909668,0.0004032875,0.00008090167,0.0002672553,0.00001911973,0.0001236473,0.0001739758,0.00002063104],"category_scores_gemma":[0.00002326913,0.000121915,0.000191815,0.0001219435,0.000262856,0.00002945742,0.00002811589,0.0001522924,3.222894e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001455412,"about_ca_system_score_gemma":0.00004265408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002780503,"about_ca_topic_score_gemma":0.00002433392,"domain_scores_codex":[0.9985954,0.0001253145,0.0006354588,0.0001965279,0.0002717114,0.0001755927],"domain_scores_gemma":[0.9990295,0.00006651826,0.0005266217,0.0001265469,0.0001779897,0.00007281658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003633309,0.00008993772,0.0002727325,0.00008660219,0.0001090917,4.578946e-7,0.0003579335,0.00008015219,0.9895265,0.00005505765,0.00003768807,0.009020564],"study_design_scores_gemma":[0.0007347581,0.0007392499,0.0003904662,0.0001754068,0.0002098861,0.0001162478,0.000409031,0.00008463619,0.9964305,0.0001711379,0.000405971,0.0001327469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962454,0.002480074,0.0006597781,0.0001673708,0.0002291112,0.0001618971,0.00004135239,0.000002285176,0.00001271985],"genre_scores_gemma":[0.9967101,0.002061666,0.0009785139,0.00001392087,0.0001883868,0.000002075704,0.000007229353,0.00002135351,0.00001681593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008887817,"threshold_uncertainty_score":0.4971548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005296678289089595,"score_gpt":0.1957606336278905,"score_spread":0.1904639553388009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}