{"id":"W2137369730","doi":"10.1128/iai.01540-07","title":"Analysis of the<i>Actinobacillus pleuropneumoniae</i>ArcA Regulon Identifies Fumarate Reductase as a Determinant of Virulence","year":2008,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Microbial infections and disease research","field":"Immunology and Microbiology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; Deutsche Forschungsgemeinschaft; Ministry of Education, Libya","keywords":"Biology; Actinobacillus pleuropneumoniae; Regulon; Microbiology; Virulence; Reductase; Biochemistry; Mutant; Escherichia coli; Citric acid cycle; Enzyme; Gene; Serotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001044572,0.0004399933,0.0002687961,0.0002782935,0.0001170648,0.0002475773,0.0001486799,0.0002005837,0.0003963386],"category_scores_gemma":[0.0001555153,0.0001274797,0.0003593548,0.0002411898,0.0001578245,0.0001315241,0.0001823715,0.0003552618,0.0002511461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001988476,"about_ca_system_score_gemma":0.0001169002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009305674,"about_ca_topic_score_gemma":0.0005891038,"domain_scores_codex":[0.9998729,0.00001900327,0.00001070376,0.00003542854,0.00003570328,0.00002610295],"domain_scores_gemma":[0.9998994,0.00001990232,0.00003533183,0.00001134395,0.00001634334,0.00001769887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000431207,0.000008773619,0.0004895579,0.00001137279,0.000002266361,0.00001751521,0.000005582311,0.00003018915,0.9989987,0.00001168973,0.000006376865,0.0003749375],"study_design_scores_gemma":[0.000008035914,0.0002995769,0.1051358,0.000009306831,0.00003728236,0.0004284967,0.00008075067,0.002624881,0.8901182,0.00009554601,0.001155421,0.000006764222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957693,0.0004722434,0.00216532,0.00009958431,0.000007706556,0.00001561192,0.0009001259,0.0000489586,0.0005211813],"genre_scores_gemma":[0.993952,0.0004095102,0.002488497,0.00008210764,0.00001011888,0.00002919684,0.002290386,0.00002125546,0.0007169347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009305674,"threshold_uncertainty_score":0.001850247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02150118294388773,"score_gpt":0.2737944372970168,"score_spread":0.252293254353129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}