{"id":"W2137372992","doi":"10.4161/epi.5.4.11522","title":"Crosstalk between histone modifications maintains the developmental pattern of gene expression on a tissue-specific locus","year":2010,"lang":"en","type":"article","venue":"Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Biology; Chromatin; Genetics; Enhancer; Crosstalk; Histone; Locus (genetics); Regulation of gene expression; Gene; Locus control region; Gene cluster; Gene expression; Epigenetics; Computational biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000245839,0.0002063459,0.0002527348,0.0002825996,0.00022144,0.0005880029,0.0002770474,0.0001974765,0.001271363],"category_scores_gemma":[0.0002939793,0.000212486,0.0001261867,0.0002107337,0.0003610037,0.0003520434,0.0004569479,0.0003758734,0.0004798202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003330123,"about_ca_system_score_gemma":0.0002479519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000253222,"about_ca_topic_score_gemma":0.0007356927,"domain_scores_codex":[0.9997776,0.00003419378,0.00001151382,0.00009371238,0.00004096685,0.00004193131],"domain_scores_gemma":[0.9996821,0.00006826124,0.00007674401,0.00006236947,0.00003970851,0.00007086649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003266625,0.000004437221,0.001136889,0.000007855481,0.000005573723,0.00002948471,0.00001514412,0.00003882522,0.9961747,0.0001795316,0.00001349977,0.002361391],"study_design_scores_gemma":[0.00001845966,0.0003041545,0.08970246,0.00000999117,0.00004810314,0.0004709092,0.0001564439,0.002114429,0.9024469,0.000926117,0.00378606,0.00001581702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877933,0.001469078,0.008124307,0.0001390352,0.00001608169,0.00001080405,0.0001687051,0.000143923,0.002134821],"genre_scores_gemma":[0.996881,0.0002708361,0.001404267,0.00004534866,0.000008425644,0.000005929754,0.0001432981,0.00002495301,0.001215838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001271363,"threshold_uncertainty_score":0.004253149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02182724915755858,"score_gpt":0.2901042096784409,"score_spread":0.2682769605208823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}