{"id":"W2137389752","doi":"10.1021/jo048216x","title":"[4+2] Cycloaddition of 2-Substituted 1,2-Dihydropyridines with Nitrosobenzene:  Asymmetric Synthesis of <i>trans</i>-2-Substituted 3-Amino-1,2,3,6-tetrahydropyridines","year":2005,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Advanced Synthetic Organic Chemistry","field":"Chemistry","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Nitrosobenzene; Cycloaddition; Chemistry; Pyridine; Methanol; Medicinal chemistry; Stereoselectivity; Amide; Catalysis; Combinatorial chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001562677,0.0005095767,0.000315832,0.0002147098,0.0002285047,0.0002037321,0.0005071841,0.000284009,0.002188371],"category_scores_gemma":[0.0001091245,0.000214073,0.0001947569,0.0002006549,0.0002220885,0.0002352879,0.0002565763,0.0004654293,0.0009712846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004184553,"about_ca_system_score_gemma":0.0003825566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001188035,"about_ca_topic_score_gemma":0.003852759,"domain_scores_codex":[0.9998277,0.0000263641,0.00001158979,0.00003195543,0.00003750859,0.00006485781],"domain_scores_gemma":[0.9999309,0.000008516701,0.00002116682,0.000008974572,0.00001128048,0.000019109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007388427,0.00003981024,0.00007437362,0.0001223749,0.000007271644,0.0003356237,0.00005426252,0.0002740572,0.9936303,0.0009882157,0.0003381169,0.004061589],"study_design_scores_gemma":[0.00001988476,0.0002524409,0.0006643138,0.000006918559,0.000009351264,0.000466293,0.00001550721,0.0007625109,0.9909781,0.0001143643,0.006697617,0.00001271104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8985242,0.006085832,0.04356314,0.0004717885,0.000539545,0.0002302567,0.0009046515,0.0007330796,0.04894735],"genre_scores_gemma":[0.9786153,0.002910011,0.01200553,0.0001443312,0.00004873964,0.00006539829,0.0003539754,0.00006697624,0.005789684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002188371,"threshold_uncertainty_score":0.007320881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0054681470484788,"score_gpt":0.2012224556426894,"score_spread":0.1957543085942106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}