{"id":"W2137394989","doi":"10.1093/toxsci/kfj036","title":"The Effects of Methotrexate on Drosophila Development, Female Fecundity, and Gene Expression","year":2005,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Biology; Dihydrofolate reductase; Drosophila melanogaster; Antifolate; Sterility; Gene; Microarray analysis techniques; Gene expression; Genetics; Cell biology; Antimetabolite; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005659213,0.0002167174,0.0001165539,0.0002605496,0.0001671907,0.0001932117,0.0001100541,0.000213102,0.0007960879],"category_scores_gemma":[0.00008355243,0.0001080812,0.0001840171,0.0001081899,0.0001460943,0.00009783987,0.0001022902,0.0003110864,0.0001742636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004233965,"about_ca_system_score_gemma":0.0001343542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001853294,"about_ca_topic_score_gemma":0.003622386,"domain_scores_codex":[0.9999141,0.00001356159,0.000008439344,0.00002878321,0.00002091499,0.00001421529],"domain_scores_gemma":[0.9999257,0.0000174396,0.00002649759,0.000005941289,0.000009576348,0.00001485741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009238451,0.0000133659,0.0006648904,0.00003057176,0.000004608098,0.00004145995,0.00001417246,0.00004138813,0.9974604,0.00002753575,0.00004294833,0.001566212],"study_design_scores_gemma":[0.00001069206,0.0003992032,0.04497508,0.000006558232,0.0000255601,0.0001705983,0.00005268444,0.0006373958,0.9508386,0.00002775674,0.002848795,0.000007152784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931481,0.002920454,0.0007244141,0.0001127209,0.0000212349,0.00001694193,0.001347822,0.00004047501,0.001667834],"genre_scores_gemma":[0.9912488,0.001801593,0.00119289,0.00008586768,0.000008190788,0.00003270599,0.001027084,0.0000141542,0.004588581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001853294,"threshold_uncertainty_score":0.003684998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02366213736228943,"score_gpt":0.3028790307200623,"score_spread":0.2792168933577728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}