{"id":"W2137414549","doi":"10.1016/s1474-4422(11)70070-9","title":"Development of biomarkers for Huntington's disease","year":2011,"lang":"en","type":"review","venue":"The Lancet Neurology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":161,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institutes of Health","keywords":"Disease; Huntington's disease; Medicine; Clinical trial; Population; Intervention (counseling); Genetic testing; Biomarker; Bioinformatics; Pathology; Internal medicine; Psychiatry; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002571607,0.0003921621,0.001259224,0.0001215669,0.0001639943,0.00001524685,0.001276283,0.0001026266,0.00004671499],"category_scores_gemma":[0.0008997351,0.0002542278,0.0003563036,0.0002267221,0.0003422801,0.00002273402,0.0003021514,0.0002232981,0.00005774694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008301109,"about_ca_system_score_gemma":0.0004143153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":7.290827e-7,"about_ca_topic_score_gemma":0.000002123539,"domain_scores_codex":[0.9973515,0.0006684934,0.0005855334,0.0007285806,0.0001520804,0.000513795],"domain_scores_gemma":[0.9974883,0.0009072276,0.0005692029,0.0008774026,0.00003846357,0.0001193751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004134789,0.0001894211,0.00002174533,0.009890185,0.00009640039,0.0000110998,0.0001363224,0.000003235648,0.0008395698,0.004299474,0.003053816,0.9810452],"study_design_scores_gemma":[0.0002048412,0.00006007006,0.00006286081,0.000195243,0.0002899211,0.000005078034,6.87174e-7,0.000004585806,0.003590897,0.0002174814,0.9951543,0.0002140952],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004535927,0.9905509,0.0001097699,0.0002782658,0.001004211,0.00237977,0.0003744153,0.00009627915,0.0006704555],"genre_scores_gemma":[0.0003897733,0.99656,0.0004492302,0.00145068,0.0002795206,0.0006751959,0.00002322425,0.0000897346,0.00008266802],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9921004,"threshold_uncertainty_score":0.999991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1657449139360142,"score_gpt":0.3520138809736791,"score_spread":0.1862689670376649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}