{"id":"W2137423957","doi":"10.1111/mmi.12771","title":"The attenuated virulence of a <scp><i>B</i></scp><i>urkholderia cenocepacia</i> <scp><i>paaABCDE</i></scp> mutant is due to inhibition of quorum sensing by release of phenylacetic acid","year":2014,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; University of Manitoba","keywords":"Phenylacetic acid; Quorum sensing; Burkholderia cenocepacia; Biology; Microbiology; Virulence; Homoserine; Mutant; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005929614,0.0004554767,0.0007224387,0.0001056076,0.0001498217,0.00002695766,0.0003548859,0.000516732,0.000003957362],"category_scores_gemma":[0.0009323038,0.0004002847,0.0002960575,0.0003637827,0.0005312332,0.000009192385,0.0003566518,0.0002141226,0.00001485995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002386369,"about_ca_system_score_gemma":0.0001031243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008560978,"about_ca_topic_score_gemma":0.00002436677,"domain_scores_codex":[0.9968953,0.0004882008,0.0009327041,0.0007574441,0.0001516488,0.0007746777],"domain_scores_gemma":[0.997602,0.0001553862,0.0007226295,0.0008991972,0.0004481156,0.0001726324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006009977,0.00009081489,0.00003132678,0.00007693547,0.000128451,0.000009465832,0.000220723,0.00001971853,0.9910671,0.00004622866,0.007056403,0.00119277],"study_design_scores_gemma":[0.0008433827,0.0007029085,0.00003891649,0.0001162147,0.00008222656,0.0001460232,0.0002702329,0.00004151556,0.9616502,0.00002971061,0.03595356,0.0001250973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943441,0.001027468,0.002778245,0.0003495036,0.0003036862,0.0004506297,0.0004168179,0.00002041431,0.0003091815],"genre_scores_gemma":[0.9964463,0.0001774063,0.001419849,0.001349377,0.00007530325,0.000005743512,0.0003471068,0.00007092318,0.000108055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02941685,"threshold_uncertainty_score":0.9998449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003909486541220175,"score_gpt":0.1939255730901802,"score_spread":0.19001608654896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}