{"id":"W2137423957","doi":"10.1111/mmi.12771","title":"The attenuated virulence of a <scp><i>B</i></scp><i>urkholderia cenocepacia</i> <scp><i>paaABCDE</i></scp> mutant is due to inhibition of quorum sensing by release of phenylacetic acid","year":2014,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; University of Manitoba","keywords":"Phenylacetic acid; Quorum sensing; Burkholderia cenocepacia; Biology; Microbiology; Virulence; Homoserine; Mutant; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009070037,0.0006849405,0.0003124793,0.0002116766,0.0001386978,0.0003500843,0.0003715425,0.0003528212,0.001539829],"category_scores_gemma":[0.0001777814,0.0001672775,0.0003125479,0.000168218,0.0002575601,0.0001729537,0.0003408566,0.0009042102,0.0005543539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003163304,"about_ca_system_score_gemma":0.0003321787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003118349,"about_ca_topic_score_gemma":0.002133113,"domain_scores_codex":[0.9996724,0.0000306312,0.0000370148,0.00005890427,0.0001400811,0.00006094241],"domain_scores_gemma":[0.9997446,0.00003895762,0.00008473917,0.00004244009,0.000030633,0.00005867092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002305446,0.00001669446,0.0000880072,0.00001094542,0.000003008975,0.00002684462,0.000004454974,0.00001431065,0.9995357,0.0000236758,0.00001538784,0.0002381099],"study_design_scores_gemma":[0.000006665059,0.0001531076,0.00551989,0.000004491558,0.000008196373,0.0003001766,0.00002938558,0.0004512969,0.9924715,0.00002355964,0.001025288,0.00000655813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937976,0.0003376751,0.003130296,0.0001651513,0.00004808001,0.00003151131,0.001237895,0.0001407595,0.001111018],"genre_scores_gemma":[0.9920461,0.0002511467,0.002771622,0.00006761108,0.000007454777,0.00003363422,0.001557115,0.00006598166,0.003199335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003118349,"threshold_uncertainty_score":0.006200373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003909486541220175,"score_gpt":0.1939255730901802,"score_spread":0.19001608654896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}