{"id":"W2137435338","doi":"10.1523/jneurosci.3593-06.2007","title":"The Ca<sup>2+</sup>-Activated K<sup>+</sup>Channel<i>KCNN4</i>/KCa3.1 Contributes to Microglia Activation and Nitric Oxide-Dependent Neurodegeneration","year":2007,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":236,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Heart and Stroke Foundation of Canada","keywords":"Microglia; Neuroprotection; Cell biology; Neurotoxicity; p38 mitogen-activated protein kinases; Nitric oxide; Chemistry; Neurodegeneration; Nitric oxide synthase; Neuroscience; MAPK/ERK pathway; Biology; Signal transduction; Inflammation; Medicine; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002727237,0.0004234322,0.0003452024,0.0001623677,0.0002393799,0.0004474338,0.0004868562,0.000460798,0.001999906],"category_scores_gemma":[0.0003964652,0.0001479496,0.0003731174,0.0001712995,0.0005144363,0.0006950593,0.0002786432,0.0005438062,0.0006545815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005702054,"about_ca_system_score_gemma":0.0003650819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007181204,"about_ca_topic_score_gemma":0.0007578546,"domain_scores_codex":[0.9997244,0.00002945815,0.0000319235,0.00004994897,0.00009327551,0.00007082072],"domain_scores_gemma":[0.9996686,0.00005183264,0.0001364319,0.00003015119,0.00006708934,0.00004583507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002826868,0.00001770848,0.0008032488,0.0001955237,0.00001149287,0.0001088393,0.00001817196,0.0001479027,0.9944615,0.0002219148,0.0002018149,0.003529175],"study_design_scores_gemma":[0.00002994115,0.0002472448,0.009686904,0.00001792498,0.00004294635,0.001001061,0.00005921528,0.001703995,0.9817758,0.0004042888,0.005014214,0.00001638262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.954128,0.01379041,0.024035,0.001416432,0.0003156762,0.000107318,0.001349019,0.0005324167,0.004325679],"genre_scores_gemma":[0.9892729,0.003013998,0.004830482,0.0001985345,0.00006731922,0.00005356132,0.000525398,0.00005049002,0.001987235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001999906,"threshold_uncertainty_score":0.006690383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02562975487440567,"score_gpt":0.2630294003642416,"score_spread":0.2373996454898359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}