{"id":"W2137435338","doi":"10.1523/jneurosci.3593-06.2007","title":"The Ca<sup>2+</sup>-Activated K<sup>+</sup>Channel<i>KCNN4</i>/KCa3.1 Contributes to Microglia Activation and Nitric Oxide-Dependent Neurodegeneration","year":2007,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":236,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Heart and Stroke Foundation of Canada","keywords":"Microglia; Neuroprotection; Cell biology; Neurotoxicity; p38 mitogen-activated protein kinases; Nitric oxide; Chemistry; Neurodegeneration; Nitric oxide synthase; Neuroscience; MAPK/ERK pathway; Biology; Signal transduction; Inflammation; Medicine; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.001933731,0.0004292583,0.0004000308,0.000736389,0.00144387,0.0008796243,0.0009031205,0.0001217622,0.000009307041],"category_scores_gemma":[0.005019205,0.0003332809,0.000145665,0.00178536,0.0002482283,0.001373891,0.0002197184,0.000725271,0.00002913984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001337562,"about_ca_system_score_gemma":0.000201093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008075894,"about_ca_topic_score_gemma":0.000003026964,"domain_scores_codex":[0.9950484,0.000597892,0.00132971,0.0008401388,0.001397584,0.0007862744],"domain_scores_gemma":[0.9965789,0.001055664,0.0008626109,0.0004997006,0.0005110094,0.0004921721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000260057,0.00009059187,0.00003729019,0.000007528536,0.000002495672,0.00008696666,0.0002152193,0.04149053,0.9550813,0.0006304081,0.00103079,0.001066752],"study_design_scores_gemma":[0.0008472248,0.0003502041,0.001235418,0.00002835462,0.00001915247,0.0005646056,0.0001661589,0.04309856,0.9478677,0.0003118729,0.005227673,0.0002830714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9631441,0.00003386675,0.03065831,0.004643385,0.0007008416,0.0006546756,0.00001605902,0.00008391406,0.00006487127],"genre_scores_gemma":[0.9878914,0.0002195887,0.0001835755,0.01071563,0.0002659371,0.00001220739,0.000001244115,0.00005140731,0.0006590083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03047473,"threshold_uncertainty_score":0.9999119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02562975487440567,"score_gpt":0.2630294003642416,"score_spread":0.2373996454898359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}