{"id":"W2137455008","doi":"10.1124/dmd.111.042879","title":"Species-Dependent and Receptor-Selective Action of Bilobalide on the Function of Constitutive Androstane Receptor and Pregnane X Receptor","year":2011,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Pregnane X receptor; Constitutive androstane receptor; CYP2B6; CYP3A4; Reporter gene; Biology; Pharmacology; Cytochrome P450; Molecular biology; Chemistry; Gene expression; Nuclear receptor; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001824184,0.0003350539,0.0004378423,0.0002056708,0.0002232066,0.0003200431,0.0002619724,0.000259198,0.003297592],"category_scores_gemma":[0.0003495109,0.0002168887,0.0003073818,0.0001532967,0.0004581122,0.0004172338,0.0002618106,0.0007321178,0.0004181855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003103829,"about_ca_system_score_gemma":0.0003839096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008933916,"about_ca_topic_score_gemma":0.0012965,"domain_scores_codex":[0.999911,0.00002227854,0.000006494067,0.00001449543,0.000008379578,0.00003746134],"domain_scores_gemma":[0.9998642,0.00003770323,0.00002021078,0.00002925536,0.00001373273,0.00003481875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006098837,0.00009896082,0.0002508765,0.00007567383,0.00002536911,0.0001070441,0.00005732248,0.00008242088,0.9893215,0.0006843734,0.0001429754,0.003054601],"study_design_scores_gemma":[0.0004251241,0.001395571,0.005990562,0.00001274436,0.0001173014,0.0006166912,0.0001239935,0.0009364436,0.9855824,0.0004093673,0.004369171,0.00002075486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954324,0.001640197,0.0008458503,0.000186635,0.00006166742,0.00002052217,0.0002105871,0.00005340939,0.001548663],"genre_scores_gemma":[0.9959926,0.0008928099,0.0004866866,0.00006286752,0.00001641361,0.00002072571,0.0003166912,0.00003021864,0.002181058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003297592,"threshold_uncertainty_score":0.01103157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09146622068972644,"score_gpt":0.3410534522227419,"score_spread":0.2495872315330155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}