{"id":"W2137467751","doi":"10.1002/cmdc.201100346","title":"Inhibition of Aminoglycoside‐Deactivating Enzymes APH(3′)‐IIIa and AAC(6′)‐Ii by Amphiphilic Paromomycin O2′′‐Ether Analogues","year":2011,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; McGill University; Université de Montréal; Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Paromomycin; Aminoglycoside; Amphiphile; Chemistry; Enzyme; Biochemistry; Pharmacology; Ether; Stereochemistry; Antibiotics; Medicine; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000200705,0.0003757604,0.000486712,0.00005762468,0.0001544985,0.00002260108,0.0001979888,0.000343576,0.001389628],"category_scores_gemma":[0.0002020428,0.0003789944,0.0001529151,0.0001986901,0.0003197151,0.0001984675,0.0001698018,0.0002983856,0.000007972859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006766808,"about_ca_system_score_gemma":0.00003540554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001821445,"about_ca_topic_score_gemma":0.000008464096,"domain_scores_codex":[0.9981968,0.00002076669,0.0005385475,0.0005546586,0.0002687074,0.0004204554],"domain_scores_gemma":[0.9986922,0.0001845235,0.0003430499,0.0005032682,0.00008925267,0.000187742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005616401,0.0002096114,0.002077868,0.0003336865,0.00008864004,0.00001020561,0.002067446,8.856935e-8,0.990814,0.0001179953,0.001292974,0.002931274],"study_design_scores_gemma":[0.0005378234,0.00002166573,0.0001862924,0.0002008948,0.00006955802,0.00002056192,0.0009457977,0.00002106904,0.9955413,0.001112897,0.0009393254,0.0004028491],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9625809,0.0008048713,0.00001021374,0.00009304706,0.00002807225,0.00006615387,0.00007493333,0.0001178134,0.03622405],"genre_scores_gemma":[0.9980692,0.00007392458,0.0003397019,0.00006128282,0.0001405612,0.0000454906,0.0001440432,0.00005384783,0.001072005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0354883,"threshold_uncertainty_score":0.9998662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02575017475551838,"score_gpt":0.2022066425353135,"score_spread":0.1764564677797952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}