{"id":"W2137482449","doi":"10.1002/cbic.201100332","title":"Synthesis, Kinetic Evaluation and Cell‐Based Analysis of C‐Alkylated Isofagomines as Chaperones of β‐Glucocerebrosidase","year":2011,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Alkylation; Enzyme; Chemistry; Biochemistry; Glucocerebrosidase; Computational biology; Combinatorial chemistry; Stereochemistry; Biology; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002106198,0.0002266335,0.0002629469,0.0001143846,0.00008877742,0.0001735112,0.0002163804,0.0002640862,0.0004456347],"category_scores_gemma":[0.000205474,0.0001029677,0.0001811003,0.0001560917,0.0001279951,0.0001751973,0.00007719277,0.0003397334,0.0001745358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002464898,"about_ca_system_score_gemma":0.0001410721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007345841,"about_ca_topic_score_gemma":0.00100605,"domain_scores_codex":[0.9999126,0.00002483639,0.00001013787,0.00001226233,0.00002404582,0.00001607015],"domain_scores_gemma":[0.9998953,0.00002439767,0.00002411651,0.00001613963,0.00002466436,0.00001541515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001488826,0.00003188139,0.00008084378,0.00002961281,0.000004659626,0.00001906632,0.00001443106,0.0001714567,0.9986161,0.00004025353,0.00001601755,0.000826699],"study_design_scores_gemma":[0.000007497023,0.0002997395,0.0004422629,0.000001761707,0.00000546552,0.00003797113,0.000006257847,0.0003339005,0.9984562,0.000006829413,0.0003995201,0.000002474275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945364,0.001921179,0.002528385,0.00003168402,0.00001201116,0.00004183479,0.0002671086,0.00002557139,0.0006358931],"genre_scores_gemma":[0.9938445,0.001159458,0.003369656,0.00001409902,0.00000387421,0.00003326905,0.0005434476,0.00001090669,0.001020822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007345841,"threshold_uncertainty_score":0.001788437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04345308489978016,"score_gpt":0.3052940315532408,"score_spread":0.2618409466534606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}