{"id":"W2137564324","doi":"10.3899/jrheum.091427","title":"677TT Genotype Is Associated with Elevated Risk of Methotrexate (MTX) Toxicity in Juvenile Idiopathic Arthritis: Treatment Outcome, Erythrocyte Concentrations of MTX and Folates, and MTHFR Polymorphisms","year":2010,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Methylenetetrahydrofolate reductase; Methotrexate; Internal medicine; Gastroenterology; Adverse effect; Antifolate; Arthritis; Genotype; Toxicity; Rheumatology; Genotyping; Antimetabolite","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003793589,0.0003126778,0.0003695389,0.0003337541,0.0002651044,0.0002949807,0.0001620637,0.0005354449,0.001177654],"category_scores_gemma":[0.001063382,0.0001664021,0.0003218094,0.0004770742,0.000199465,0.0001323185,0.0001338179,0.0003674844,0.0001759605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000170758,"about_ca_system_score_gemma":0.0001740977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001877204,"about_ca_topic_score_gemma":0.002040347,"domain_scores_codex":[0.9996383,0.000123089,0.00005529536,0.00007703785,0.00006335389,0.00004286015],"domain_scores_gemma":[0.9988614,0.0002595513,0.0005541917,0.00004942261,0.00007394292,0.0002014486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006174807,0.00005322021,0.9953453,0.000009775013,0.00007373021,0.0002317131,0.00004749746,0.00004481022,0.002388998,0.000006061496,0.00004070814,0.001140764],"study_design_scores_gemma":[0.00001809821,0.0002247849,0.9986357,0.000003083277,0.00005297627,0.0006709498,0.00003297431,0.000171325,0.0001263773,0.000009447171,0.00005212974,0.00000207545],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997209,0.0001177836,0.000030342,0.00001701394,0.000002121564,0.000001763277,0.00003463943,0.000001405137,0.00007404487],"genre_scores_gemma":[0.9997935,0.00003012733,0.00003717643,0.000008394437,0.000006721746,0.00000208911,0.00005429699,0.000001094325,0.00006668944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001877204,"threshold_uncertainty_score":0.003939569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01610102217813291,"score_gpt":0.2758004963592029,"score_spread":0.25969947418107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}