{"id":"W2137564324","doi":"10.3899/jrheum.091427","title":"677TT Genotype Is Associated with Elevated Risk of Methotrexate (MTX) Toxicity in Juvenile Idiopathic Arthritis: Treatment Outcome, Erythrocyte Concentrations of MTX and Folates, and MTHFR Polymorphisms","year":2010,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Methylenetetrahydrofolate reductase; Methotrexate; Internal medicine; Gastroenterology; Adverse effect; Antifolate; Arthritis; Genotype; Toxicity; Rheumatology; Genotyping; Antimetabolite","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001354415,0.0001463333,0.00106419,0.000173402,0.00007997765,0.000005995529,0.00009533716,0.0001533697,0.00006605875],"category_scores_gemma":[0.0005557314,0.00008924041,0.00006543627,0.0002096095,0.0004029544,0.00009066627,0.00003198349,0.0005122261,9.554158e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003938141,"about_ca_system_score_gemma":0.0003389576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009164215,"about_ca_topic_score_gemma":0.001475659,"domain_scores_codex":[0.9980698,0.000372512,0.001013651,0.0001052785,0.0002106718,0.0002281267],"domain_scores_gemma":[0.9980881,0.0003397528,0.00103703,0.0001978749,0.0002546507,0.00008263677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001090377,0.0002693356,0.940683,0.00004809341,0.0005319804,0.00003090857,0.003023917,0.000007814386,0.05081236,0.0002003496,0.00003510913,0.003266719],"study_design_scores_gemma":[0.02079405,0.005823181,0.8982605,0.001021024,0.0007312664,0.005106428,0.001737939,0.00115426,0.06376536,0.00107198,0.0002472737,0.0002867229],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913072,0.007458473,0.00007119182,0.0008163931,0.00004578738,0.0002394441,0.00001716572,0.000005709174,0.00003861013],"genre_scores_gemma":[0.9885023,0.01120987,0.0001867195,0.00003664672,0.00000252525,0.000002740135,0.000002546562,0.00001367836,0.00004292891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04242252,"threshold_uncertainty_score":0.3639118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01610102217813291,"score_gpt":0.2758004963592029,"score_spread":0.25969947418107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}