{"id":"W2137629224","doi":"10.1091/mbc.e11-06-0489","title":"Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling","year":2011,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":153,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Institutes of Health; Canadian Institutes of Health Research; Hospital for Sick Children; University of Toronto","keywords":"Phagosome; Phosphatidylinositol; Cell biology; Signal transducing adaptor protein; Biology; Phosphorylation; PI3K/AKT/mTOR pathway; Phosphatase; Inositol; Signal transduction; Biochemistry; Phagocytosis; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001328876,0.0001365559,0.0001854561,0.00002789499,0.00004240335,0.00000362505,0.0001106548,0.0001251402,0.00000466125],"category_scores_gemma":[0.00001224442,0.0001058964,0.00005168711,0.00004239753,0.0002207354,0.000002042571,0.0001121128,0.00004725248,2.786209e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002285862,"about_ca_system_score_gemma":0.00001062426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007463914,"about_ca_topic_score_gemma":0.000008939992,"domain_scores_codex":[0.9992976,0.00005886281,0.0001863763,0.0002684935,0.00004471963,0.0001439062],"domain_scores_gemma":[0.9996203,0.00001036239,0.00009168893,0.0001846873,0.00003539541,0.00005757298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006819587,0.00003200602,0.02767958,0.00004281915,0.0000451537,8.723019e-7,0.000180795,9.827004e-7,0.9711479,0.00008070828,0.00001606191,0.0007049454],"study_design_scores_gemma":[0.0003614846,0.0003450813,0.001462462,0.00001847405,0.00005035163,0.000005275346,0.00009263169,0.000004539236,0.9958044,0.0003682832,0.001368333,0.0001186777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864062,0.01024919,0.002789162,0.00008384133,0.00003219831,0.0002966461,0.00003073404,0.00000339142,0.0001086039],"genre_scores_gemma":[0.9982293,0.0004149682,0.0009920055,0.0001566816,0.000008410146,0.00001504014,0.0001260072,0.00001226157,0.00004531775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02621711,"threshold_uncertainty_score":0.4318331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01535109163747101,"score_gpt":0.2238670220663616,"score_spread":0.2085159304288906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}