{"id":"W2137635459","doi":"10.1093/ndt/gfp280","title":"Safety and tolerability of sirolimus treatment in patients with autosomal dominant polycystic kidney disease","year":2009,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Health Services and Policy Research","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Medicine; Sirolimus; Renal function; Internal medicine; Gastroenterology; Urology; Tolerability; Adverse effect; Urine; Kidney disease; Autosomal dominant polycystic kidney disease; Retinol binding protein; Urinary system; Endocrinology; Kidney","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00263528,0.0006731488,0.001817919,0.0002522317,0.0003104107,0.0006448095,0.0004108987,0.001145635,0.002007135],"category_scores_gemma":[0.002936574,0.0002401247,0.001392471,0.0003064183,0.0005849801,0.0003382438,0.0002248218,0.001346358,0.0002429988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004132944,"about_ca_system_score_gemma":0.0007894033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002636392,"about_ca_topic_score_gemma":0.0004887841,"domain_scores_codex":[0.9983819,0.00110573,0.0001260846,0.000121846,0.0001533311,0.0001112359],"domain_scores_gemma":[0.9977278,0.0008353102,0.0008661396,0.00007073639,0.0001052865,0.0003947762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9200886,0.005845566,0.01445174,0.0008126061,0.001854089,0.0001507963,0.00007319979,0.000717653,0.006001232,0.00007234747,0.0007466165,0.04918564],"study_design_scores_gemma":[0.6834916,0.2664574,0.04503701,0.00006508017,0.001151244,0.0002821881,0.0000351193,0.0009916616,0.001260084,0.0001245931,0.001080408,0.00002351912],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935064,0.004565803,0.0002569957,0.0003083028,0.00007665172,0.0004615182,0.0002324401,0.00002762511,0.0005641687],"genre_scores_gemma":[0.9969527,0.0008869011,0.000513322,0.0003685751,0.0001704132,0.000622928,0.0002857304,0.000003735498,0.0001957981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00263528,"threshold_uncertainty_score":0.01393688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003148441845504682,"score_gpt":0.2047621376026751,"score_spread":0.2016136957571704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}