{"id":"W2137644376","doi":"10.1158/0008-5472.can-10-1108","title":"Colorectal Tumors Are Effectively Eradicated by Combined Inhibition of β-Catenin, KRAS, and the Oncogenic Transcription Factor ITF2","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Associazione Italiana per la Ricerca sul Cancro","keywords":"KRAS; Small hairpin RNA; Cancer research; Oncogene; Gene silencing; Apoptosis; Blockade; In vivo; Colorectal cancer; Biology; Catenin; Medicine; Cell cycle; Cancer; Gene knockdown; Internal medicine; Wnt signaling pathway; Receptor; Signal transduction; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008889797,0.0005097035,0.0003834509,0.0003119382,0.0001026975,0.0002338592,0.0001234654,0.0001617465,0.0008916419],"category_scores_gemma":[0.00008039017,0.0001240832,0.0002210612,0.0001301909,0.0001563354,0.0001672241,0.0001919535,0.0004904907,0.0002887141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001422036,"about_ca_system_score_gemma":0.0001730897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004468239,"about_ca_topic_score_gemma":0.001299374,"domain_scores_codex":[0.9998778,0.00001502953,0.000008076398,0.00001770737,0.00004682454,0.00003448173],"domain_scores_gemma":[0.9999516,0.000005504423,0.00001512473,0.000007129914,0.000005018478,0.00001563385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001092062,0.00004330269,0.0001372594,0.00003731359,0.00001053133,0.00004220602,0.000007052553,0.00008851162,0.9942648,0.00006414002,0.00008378154,0.005112004],"study_design_scores_gemma":[0.00004559668,0.0007080883,0.002603578,0.000007678166,0.00002983726,0.0004524389,0.00001631346,0.0007541968,0.9905978,0.00003725701,0.004743344,0.000003811767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990371,0.00308201,0.003286008,0.0001376475,0.00003708458,0.00002946971,0.0001716015,0.0002734082,0.002611783],"genre_scores_gemma":[0.9933431,0.001693598,0.001565757,0.00004480713,0.00001127749,0.00003030126,0.0003248986,0.00002556483,0.002960722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008916419,"threshold_uncertainty_score":0.002982914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01872435812457016,"score_gpt":0.3050197034798051,"score_spread":0.2862953453552349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}