{"id":"W2137644376","doi":"10.1158/0008-5472.can-10-1108","title":"Colorectal Tumors Are Effectively Eradicated by Combined Inhibition of β-Catenin, KRAS, and the Oncogenic Transcription Factor ITF2","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Associazione Italiana per la Ricerca sul Cancro","keywords":"KRAS; Small hairpin RNA; Cancer research; Oncogene; Gene silencing; Apoptosis; Blockade; In vivo; Colorectal cancer; Biology; Catenin; Medicine; Cell cycle; Cancer; Gene knockdown; Internal medicine; Wnt signaling pathway; Receptor; Signal transduction; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006401308,0.0001292915,0.0001805215,0.00006198865,0.0001700453,0.00003057104,0.0001757071,0.0001613673,0.00008363617],"category_scores_gemma":[0.00008629261,0.0000949344,0.00006213411,0.0002134162,0.0007484964,0.000007279117,0.00006150265,0.000379355,0.000003595412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003526518,"about_ca_system_score_gemma":0.0001808236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001994075,"about_ca_topic_score_gemma":0.000114115,"domain_scores_codex":[0.9986984,0.0002084089,0.0001939298,0.000314624,0.0003069047,0.000277738],"domain_scores_gemma":[0.999328,0.00005858949,0.00008677213,0.0001443428,0.0003074903,0.00007476669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001269012,0.00003706626,0.003576373,0.00003634175,0.00007274454,8.529775e-7,0.0001974224,0.000001173682,0.9906126,0.00003917029,0.003293382,0.0008638483],"study_design_scores_gemma":[0.002352803,0.0002071578,0.01155233,0.00003611372,0.00001350641,0.000003091647,0.00006733354,0.00001496169,0.983396,0.0001116281,0.002123585,0.0001214867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972124,0.001268179,0.00004702749,0.0006124465,0.0001466096,0.0005205962,0.00009400849,0.00001021618,0.0000885162],"genre_scores_gemma":[0.9985668,0.0004669291,0.0000160852,0.00005577251,0.0001087741,0.0003021333,0.00009857172,0.00002239625,0.0003625151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007975956,"threshold_uncertainty_score":0.3871312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01872435812457016,"score_gpt":0.3050197034798051,"score_spread":0.2862953453552349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}