{"id":"W2137645432","doi":"10.1039/b202643k","title":"Synthesis of pseudoxazolones and their inhibition of the 3C cysteine proteinases from hepatitis A virus and human rhinovirus-14","year":2002,"lang":"en","type":"article","venue":"Journal of the Chemical Society Perkin Transactions 1","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Picornavirus; Rhinovirus; Glyoxylic acid; Thioether; Chemistry; Enzyme; Imine; Virology; Cysteine; Stereochemistry; Biochemistry; Virus; Biology; RNA; Catalysis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000223365,0.0005428417,0.0003456604,0.0002549658,0.0001540483,0.0002130175,0.0003590642,0.0003587722,0.001161908],"category_scores_gemma":[0.000297089,0.0002419593,0.0003715248,0.000176655,0.0001926084,0.0002387385,0.0001846106,0.0003565484,0.0003532139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002495169,"about_ca_system_score_gemma":0.0003742299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004936332,"about_ca_topic_score_gemma":0.000985128,"domain_scores_codex":[0.9998462,0.00003838352,0.00001955158,0.00002243007,0.00004079153,0.00003267595],"domain_scores_gemma":[0.9998575,0.00002658277,0.00003892778,0.00001782356,0.00002905131,0.00002999369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000251295,0.00004952792,0.00008484229,0.0002073245,0.00001367606,0.0001535793,0.00004489991,0.0003828819,0.991962,0.0002996923,0.0001014964,0.006448832],"study_design_scores_gemma":[0.00008334366,0.001332473,0.0009768513,0.00001335972,0.00002230193,0.0002760704,0.00001476274,0.000432122,0.9914274,0.00006067539,0.005347044,0.00001363608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.970089,0.01330743,0.009929684,0.0001359759,0.0001648818,0.0002709531,0.0008946821,0.0001177471,0.005089606],"genre_scores_gemma":[0.9772963,0.006871853,0.01001389,0.00007807052,0.00003174414,0.0001475732,0.001008896,0.00002646841,0.004525326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001161908,"threshold_uncertainty_score":0.003886938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0191657263565763,"score_gpt":0.244728362288766,"score_spread":0.2255626359321898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}