{"id":"W2137645432","doi":"10.1039/b202643k","title":"Synthesis of pseudoxazolones and their inhibition of the 3C cysteine proteinases from hepatitis A virus and human rhinovirus-14","year":2002,"lang":"en","type":"article","venue":"Journal of the Chemical Society Perkin Transactions 1","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Picornavirus; Rhinovirus; Glyoxylic acid; Thioether; Chemistry; Enzyme; Imine; Virology; Cysteine; Stereochemistry; Biochemistry; Virus; Biology; RNA; Catalysis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001617687,0.0001004126,0.0003036204,0.00002662354,0.0001989123,0.00001012807,0.00008710308,0.0001268947,0.0001477481],"category_scores_gemma":[0.00007586349,0.00005289924,0.0003685824,0.0001939165,0.000601034,0.00008628806,0.00002005084,0.0004662084,3.58769e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004987544,"about_ca_system_score_gemma":0.00002261454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005235764,"about_ca_topic_score_gemma":0.00003070044,"domain_scores_codex":[0.999199,0.00007015611,0.0003568298,0.00009236885,0.0001760766,0.0001055376],"domain_scores_gemma":[0.999272,0.0001535622,0.0002163171,0.000171995,0.0001436231,0.00004249326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004531338,0.0002861125,0.00410806,0.00007043609,0.0002631432,5.026751e-7,0.0006014385,0.00000206407,0.9914755,0.000006710562,0.0001709663,0.00296974],"study_design_scores_gemma":[0.0007091898,0.0002121861,0.01754057,0.0003963556,0.0002215749,0.0001652541,0.0002460902,0.0001467343,0.979865,0.0001802081,0.0002622773,0.00005460665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994937,0.001377,0.0002474634,0.003129849,0.00004669661,0.0001774573,0.00004668514,0.000004785103,0.00003303534],"genre_scores_gemma":[0.9977364,0.001812966,0.0002358443,0.00005148196,0.00005398546,0.000009862192,4.675904e-7,0.000009335399,0.00008965382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01343251,"threshold_uncertainty_score":0.2214535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0191657263565763,"score_gpt":0.244728362288766,"score_spread":0.2255626359321898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}