{"id":"W2137718639","doi":"10.1093/protein/15.7.561","title":"Photo-control of peptide helix content by an azobenzene cross-linker: steric interactions with underlying residues are not critical","year":2002,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Photochromic and Fluorescence Chemistry","field":"Materials Science","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Azobenzene; Steric effects; Linker; Helix (gastropod); Chemistry; Peptide; Crystallography; Stereochemistry; Biochemistry; Molecule; Computer science; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001473706,0.0002185878,0.0001620358,0.00005853134,0.00009113516,0.0001848205,0.0001553671,0.0002836418,0.000580693],"category_scores_gemma":[0.0001721566,0.0000767274,0.0001385424,0.00007879842,0.0002096743,0.0001791367,0.00009211231,0.0004146907,0.0001662561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000151279,"about_ca_system_score_gemma":0.00008552158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002123619,"about_ca_topic_score_gemma":0.0002933264,"domain_scores_codex":[0.9999171,0.00001433965,0.000005218281,0.00002029586,0.00002165167,0.00002128292],"domain_scores_gemma":[0.9997951,0.00006632479,0.0000710273,0.00001920793,0.00002138531,0.00002692611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002779002,0.000003645313,0.00003927196,0.000009759048,0.000001298441,0.0000135586,0.000003527694,0.00001650554,0.9996623,0.000009343622,0.00000179004,0.0002112576],"study_design_scores_gemma":[0.000002437094,0.00008010262,0.0006281276,8.978231e-7,0.000003166489,0.00005119454,0.000003804936,0.00009743641,0.9989529,0.000006805269,0.0001719239,0.000001219735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971635,0.0004558139,0.001785539,0.00003249647,0.000005261387,0.000013584,0.00003739965,0.00001622635,0.000490239],"genre_scores_gemma":[0.9968895,0.0002802816,0.002196563,0.00003611282,0.000003444341,0.00001251629,0.00007028576,0.000008903593,0.0005023511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000580693,"threshold_uncertainty_score":0.001942635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04705214105737452,"score_gpt":0.2591396942431305,"score_spread":0.212087553185756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}