{"id":"W2137729619","doi":"10.4049/jimmunol.171.2.528","title":"Cutting Edge: MHC Class II-Restricted Peptides Containing the Inflammation-Associated Marker 3-Nitrotyrosine Evade Central Tolerance and Elicit a Robust Cell-Mediated Immune Response","year":2003,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; NovAtel (Canada); University of Ottawa; Ottawa Regional Cancer Foundation","funders":"Canadian Institutes of Health Research; Canadian Arthritis Network; University of California, San Diego; National Institutes of Health; Arthritis Society","keywords":"Nitrotyrosine; Epitope; T cell; Immunogenicity; Immune system; T-cell receptor; Biology; Molecular biology; Immune tolerance; Chemistry; Antibody; Immunology; Biochemistry; Nitric oxide synthase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002220385,0.0002821297,0.0004852383,0.0002224705,0.001016999,0.00004380435,0.0003767402,0.0003369851,0.0005550655],"category_scores_gemma":[0.00290661,0.0001780016,0.0001525968,0.0003608972,0.0004245619,0.0002720329,0.0001011023,0.00147241,0.00007065896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001813874,"about_ca_system_score_gemma":0.0002019895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008857925,"about_ca_topic_score_gemma":0.000009537058,"domain_scores_codex":[0.994777,0.003332159,0.001065928,0.0001611923,0.00008832104,0.0005754103],"domain_scores_gemma":[0.9957071,0.002156055,0.001320461,0.0003142469,0.0004748709,0.0000272755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008098766,0.0001170005,0.001052021,0.000005589035,0.0005336162,0.000006899907,0.002575788,0.0003062497,0.983648,0.00006873887,0.002984659,0.0006026512],"study_design_scores_gemma":[0.01672817,0.004429847,0.3605241,0.0004243648,0.0007101366,0.003989155,0.01740591,0.000567826,0.3795752,0.00009451714,0.21476,0.0007907653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819917,0.0113798,0.0001671031,0.002642392,0.002918403,0.0002736685,0.000003464784,0.00003915397,0.0005843216],"genre_scores_gemma":[0.9944237,0.00135822,0.00003006561,0.0003480085,0.00006745074,0.000008418273,0.00002220103,0.00002788953,0.003714007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6040728,"threshold_uncertainty_score":0.7822041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009148504345294763,"score_gpt":0.210378220078787,"score_spread":0.2012297157334923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}