{"id":"W2137729619","doi":"10.4049/jimmunol.171.2.528","title":"Cutting Edge: MHC Class II-Restricted Peptides Containing the Inflammation-Associated Marker 3-Nitrotyrosine Evade Central Tolerance and Elicit a Robust Cell-Mediated Immune Response","year":2003,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; NovAtel (Canada); University of Ottawa; Ottawa Regional Cancer Foundation","funders":"Canadian Institutes of Health Research; Canadian Arthritis Network; University of California, San Diego; National Institutes of Health; Arthritis Society","keywords":"Nitrotyrosine; Epitope; T cell; Immunogenicity; Immune system; T-cell receptor; Biology; Molecular biology; Immune tolerance; Chemistry; Antibody; Immunology; Biochemistry; Nitric oxide synthase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002077799,0.0004695996,0.000289763,0.0001105944,0.0001040831,0.0003578154,0.0001737291,0.0005099256,0.001748625],"category_scores_gemma":[0.0001217356,0.0001084834,0.000159357,0.00007416926,0.0002902508,0.0002681424,0.0001807671,0.0009033986,0.0005944477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001597185,"about_ca_system_score_gemma":0.0001096118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008671288,"about_ca_topic_score_gemma":0.0001579391,"domain_scores_codex":[0.9998109,0.00002975159,0.00001407319,0.00003869183,0.00004974075,0.0000569901],"domain_scores_gemma":[0.9998474,0.00003721029,0.0000366587,0.00002341016,0.00001996425,0.0000353184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008596802,0.00001383747,0.00006914632,0.00003691555,0.000001461678,0.00004113818,0.000006154387,0.00001642082,0.9984629,0.000103681,0.00005312119,0.001109342],"study_design_scores_gemma":[0.00004120253,0.0004761154,0.002806546,0.00001377823,0.00001065809,0.0008483628,0.00002456957,0.0005930824,0.9927609,0.0001662073,0.002255355,0.000003175174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882535,0.002631828,0.005467637,0.0003296233,0.00009404687,0.00002797809,0.000156927,0.0001547064,0.002883877],"genre_scores_gemma":[0.9929523,0.0007065984,0.003438015,0.0002075575,0.00003961763,0.00001604709,0.0001813259,0.00002655756,0.002431936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001748625,"threshold_uncertainty_score":0.005849719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009148504345294763,"score_gpt":0.210378220078787,"score_spread":0.2012297157334923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}