{"id":"W2137773374","doi":"10.1002/jnr.22733","title":"Proline substitutions and threonine pseudophosphorylation of the SH3 ligand of 18.5‐kDa myelin basic protein decrease its affinity for the Fyn‐SH3 domain and alter process development and protein localization in oligodendrocytes","year":2011,"lang":"en","type":"article","venue":"Journal of Neuroscience Research","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto; University of Guelph","funders":"Canadian Institutes of Health Research","keywords":"SH3 domain; FYN; Myelin basic protein; Biology; Cell biology; Proto-oncogene tyrosine-protein kinase Src; Phosphorylation; Biochemistry; Gene isoform; Myelin; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001977075,0.0001412318,0.0002260471,0.0002746774,0.000468153,0.00006472567,0.0004039969,0.00004728813,0.000002975594],"category_scores_gemma":[0.004000249,0.00008430743,0.00003388411,0.0009292723,0.0007340693,0.0003482319,0.0001871379,0.0003095803,1.479161e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002163903,"about_ca_system_score_gemma":0.0004845517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008729834,"about_ca_topic_score_gemma":0.00002144182,"domain_scores_codex":[0.9975584,0.0003504437,0.0005818739,0.00034726,0.0008465918,0.0003154619],"domain_scores_gemma":[0.9984869,0.0004298346,0.0003858536,0.0001690166,0.0003769572,0.0001514358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003623876,0.0002031534,0.000848379,0.0001650367,0.000001316327,0.00001299036,0.0006385667,0.00009070135,0.9952134,0.002030166,0.00000147087,0.0004324223],"study_design_scores_gemma":[0.0006415357,0.0005150988,0.01416115,0.0002120112,0.000007330381,0.0001442794,0.0000875751,0.004680157,0.9785418,0.0009056153,0.00002816134,0.0000752842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964862,0.000153976,0.001464642,0.0002776544,0.00005994536,0.001532558,0.000009068637,0.000003738403,0.00001223406],"genre_scores_gemma":[0.9993403,0.0001701915,0.0003179206,0.00005426888,0.00001807481,0.00006648098,6.634095e-8,0.00001267028,0.00002000788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01667161,"threshold_uncertainty_score":0.4788961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1587116051310725,"score_gpt":0.3469433360282772,"score_spread":0.1882317308972047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}