{"id":"W2137785350","doi":"10.1091/mbc.e05-10-0918","title":"Akt Binds to and Phosphorylates Phospholipase C-γ1 in Response to Epidermal Growth Factor","year":2006,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale","keywords":"Biology; Phosphorylation; Epidermal growth factor; Cell biology; Proto-Oncogene Proteins c-akt; Protein kinase B; Growth factor; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002783074,0.0001692003,0.0001828208,0.00009716959,0.00004889761,0.00000850487,0.0002223103,0.0001749553,0.00001286165],"category_scores_gemma":[0.0001517617,0.0001380849,0.00008835737,0.0001970739,0.0001007677,0.00000190596,0.0002425722,0.00007812525,0.000006319299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001540216,"about_ca_system_score_gemma":0.00004607271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001720616,"about_ca_topic_score_gemma":0.00002701473,"domain_scores_codex":[0.9988312,0.0002182087,0.0002548844,0.0003559885,0.00007322033,0.000266568],"domain_scores_gemma":[0.999431,0.00002232436,0.00007585187,0.0003277892,0.00005606698,0.00008693407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004186962,0.00004577541,0.005591096,0.00001029888,0.000007659963,0.000006025914,0.00003186569,0.0002622447,0.9930957,0.0001165872,0.0001641268,0.0002499058],"study_design_scores_gemma":[0.0005262312,0.0002062613,0.01272369,0.00001629888,0.000006452161,0.000005450175,0.00001029199,0.00001532515,0.9823492,0.0003652107,0.003606315,0.0001692368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995141,0.001311686,0.00183271,0.001117076,0.0000650072,0.0003519648,0.0000355922,0.000006899276,0.0001380877],"genre_scores_gemma":[0.9975218,0.000006888733,0.001244892,0.0008353509,0.00002679272,0.0000241825,0.00002059601,0.00001852605,0.0003010036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01074648,"threshold_uncertainty_score":0.563094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004933175383042805,"score_gpt":0.2292812140838672,"score_spread":0.2243480387008244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}