{"id":"W2137792649","doi":"10.1158/0008-5472.can-09-0024","title":"Oncogenic Kras Requires Simultaneous PI3K Signaling to Induce ERK Activation and Transform Thyroid Epithelial Cells <i>In vivo</i>","year":2009,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health","keywords":"MAPK/ERK pathway; KRAS; PTEN; Cancer research; PI3K/AKT/mTOR pathway; Kinase; Biology; Signal transduction; Thyroid cancer; Follicular thyroid cancer; Cell biology; Thyroid; Cancer; Papillary thyroid cancer; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007155177,0.0001917957,0.0003145837,0.0004373219,0.00013832,0.00004837681,0.000159226,0.0002041487,0.0001549136],"category_scores_gemma":[0.0002446807,0.0001865354,0.00006712028,0.0009593039,0.0000953791,0.000110309,0.00003560343,0.0008524508,0.0000387768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008885676,"about_ca_system_score_gemma":0.0006652945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007817483,"about_ca_topic_score_gemma":0.0001981688,"domain_scores_codex":[0.9974873,0.0001163754,0.0003236676,0.0005419712,0.0008264129,0.0007042796],"domain_scores_gemma":[0.9987881,0.0002592478,0.00003847233,0.000320584,0.0002503456,0.0003433103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00122766,0.00008716575,0.00001148356,0.0000533203,0.00002366633,0.0001542744,0.001281045,0.001328658,0.9536901,0.0000390638,0.0008649914,0.04123854],"study_design_scores_gemma":[0.001921795,0.001236524,0.00007155317,0.0004015853,0.00002061801,0.00001904851,0.0001944855,0.0002478361,0.9824492,0.0002648265,0.01298185,0.0001907059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990576,0.001096752,0.0004054188,0.004288726,0.0001113656,0.001388105,0.00004062013,0.00005306721,0.002039982],"genre_scores_gemma":[0.9969409,0.0007198161,0.0001793875,0.000871274,0.0003567509,0.00009426883,0.000006239359,0.00004326074,0.0007880706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04104784,"threshold_uncertainty_score":0.7606691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04119421789582388,"score_gpt":0.3615672523183889,"score_spread":0.320373034422565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}