{"id":"W2137811518","doi":"10.1093/gbe/evv045","title":"Unexpected Ancient Paralogs and an Evolutionary Model for the COPII Coat Complex","year":2015,"lang":"en","type":"article","venue":"Genome Biology and Evolution","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; National Institute of Environmental Health Sciences; Alberta Innovates; Alberta Innovates - Technology Futures","keywords":"COPII; Biology; COPI; Most recent common ancestor; Eukaryote; Evolutionary biology; Phylogenetics; Endoplasmic reticulum; Phylogenetic tree; Golgi apparatus; Genetics; Genome; Gene; Secretory pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002455012,0.0003725682,0.0003463675,0.0007784223,0.001008331,0.0007817996,0.0004843565,0.0005153912,0.001272274],"category_scores_gemma":[0.0003815801,0.0001792391,0.0002164398,0.0008272502,0.0008621842,0.001147248,0.0006539031,0.0006763983,0.0005598683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000518645,"about_ca_system_score_gemma":0.0003597725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007248696,"about_ca_topic_score_gemma":0.001005012,"domain_scores_codex":[0.9998598,0.00001481627,0.000009022746,0.00007012011,0.00002358214,0.00002260466],"domain_scores_gemma":[0.9997508,0.00003811759,0.00007063392,0.00004536957,0.00004067926,0.00005435808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0008405131,0.00009876863,0.09460599,0.0005519963,0.0001536525,0.005563918,0.002180586,0.001788231,0.8333526,0.01312645,0.0005201766,0.04721712],"study_design_scores_gemma":[0.00009395053,0.0006330854,0.7688678,0.0002296738,0.0004238676,0.01605986,0.004776376,0.01701726,0.07739644,0.01723264,0.09712164,0.0001474327],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883128,0.002609638,0.006553363,0.0002763925,0.00002449609,0.00001175504,0.0002146928,0.00009998138,0.001896904],"genre_scores_gemma":[0.9910032,0.002063802,0.004914972,0.0001289874,0.00003626482,0.0000112871,0.0005637488,0.00004122166,0.001236529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001272274,"threshold_uncertainty_score":0.004256129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04045443486722315,"score_gpt":0.273040532738035,"score_spread":0.2325860978708119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}