{"id":"W2137835411","doi":"10.1101/gad.1208404","title":"Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling","year":2004,"lang":"en","type":"article","venue":"Genes & Development","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":188,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Biology; Neural stem cell; Embryonic stem cell; Epiblast; Stem cell; Neurosphere; Cell biology; Neuroepithelial cell; Adult stem cell; Induced stem cells; Notch signaling pathway; Neural cell; Neural development; Precursor cell; Embryo; Embryogenesis; Cell; Genetics; Signal transduction; Gastrulation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002332742,0.0004904247,0.0004527013,0.00008691214,0.000589916,0.0001595159,0.0008718423,0.0000773557,0.00003688351],"category_scores_gemma":[0.00001524388,0.0003090607,0.0001746159,0.0003880606,0.0001424318,0.0001003806,0.0003595031,0.0002660871,0.0001463002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009679954,"about_ca_system_score_gemma":0.0001783512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003631909,"about_ca_topic_score_gemma":0.00005189229,"domain_scores_codex":[0.9963261,0.0005493299,0.0007155532,0.0008721359,0.0008133711,0.0007234339],"domain_scores_gemma":[0.9976096,0.001276426,0.0003349435,0.000458834,0.0001148299,0.0002053887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001489938,0.0001076778,0.0000878171,0.00001059064,0.00003371225,0.00004890166,0.001463583,0.01008728,0.9838047,0.000551909,0.00001143062,0.003643384],"study_design_scores_gemma":[0.0009674515,0.0001693653,0.003841243,0.00004896755,0.00006934701,0.00001311823,0.0007284418,0.0002591508,0.9932753,0.00005188605,0.0002279209,0.0003478153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847004,0.00007504562,0.01181898,0.0007632998,0.001352071,0.001036289,0.0001709085,0.00006379002,0.00001921123],"genre_scores_gemma":[0.9942373,0.00003481463,0.0002052681,0.005179186,0.00009235981,0.00009642482,0.00000228427,0.00006830187,0.00008407218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01161371,"threshold_uncertainty_score":0.9999362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04436466962580425,"score_gpt":0.2270330156237676,"score_spread":0.1826683459979633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}