{"id":"W2137845928","doi":"10.1111/jre.12223","title":"Long‐term exposure of human gingival fibroblasts to cigarette smoke condensate reduces cell growth by modulating <scp>B</scp>ax, <scp>c</scp>aspase‐3 and <scp>p</scp>53 expression","year":2014,"lang":"en","type":"article","venue":"Journal of Periodontal Research","topic":"Oral microbiology and periodontitis research","field":"Dentistry","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"China Scholarship Council; King Saud University; Fondation de l’Université Laval","keywords":"Chemistry; Propidium iodide; Fibroblast; Cell growth; Molecular biology; Apoptosis; Cell; Viability assay; Cell cycle; Cancer research; Programmed cell death; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.004894201,0.0006919678,0.001410206,0.001203367,0.001170239,0.0007773304,0.0016314,0.0007617364,0.000141081],"category_scores_gemma":[0.006623894,0.00061574,0.0004950997,0.0008095895,0.001060668,0.0008853947,0.001308371,0.003190295,0.00009674164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002650008,"about_ca_system_score_gemma":0.0003204819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002863599,"about_ca_topic_score_gemma":0.0001654801,"domain_scores_codex":[0.9911278,0.001922729,0.001599458,0.001047063,0.002313943,0.00198896],"domain_scores_gemma":[0.9917576,0.003707534,0.000902612,0.0007564783,0.001688085,0.001187645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006646517,0.0003088228,0.1341344,0.0004580688,0.0001383783,0.000433181,0.004711243,0.00002297078,0.8209653,0.0000246644,0.03812559,0.0006108984],"study_design_scores_gemma":[0.002898039,0.003833225,0.2247025,0.001183533,0.00005263777,0.0007456399,0.004661991,0.00008479167,0.7580061,0.0001551588,0.003525285,0.0001510993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927657,0.002686906,0.00006872685,0.00009754507,0.0005199415,0.0006361204,0.0002386455,0.00004622095,0.002940167],"genre_scores_gemma":[0.9845644,0.0001936708,0.0002894376,0.00005883592,0.0009160305,0.00002400543,0.00006628624,0.0001408315,0.01374646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09056806,"threshold_uncertainty_score":0.9996294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03456587314680973,"score_gpt":0.3316938795580125,"score_spread":0.2971280064112028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}