{"id":"W2137864841","doi":"10.1074/jbc.m303164200","title":"Human Combinatorial Fab Library Yielding Specific and Functional Antibodies against the Human Fibroblast Growth Factor Receptor 3","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"MorphoSys; School of Medicine, New York University; York University","keywords":"Antibody; Complementarity determining region; Monoclonal antibody; Immunoglobulin light chain; Molecular biology; Flow cytometry; Receptor; Recombinant DNA; Biology; Immunoglobulin Fab Fragments; Chemistry; Biochemistry; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002870119,0.0005691897,0.0006039819,0.0006481585,0.0001905841,0.0003562722,0.0003804503,0.0003311612,0.001494832],"category_scores_gemma":[0.0002214924,0.0001703338,0.0003641239,0.0004949612,0.0001406581,0.0001358296,0.0003157787,0.0004003354,0.0007989948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004532937,"about_ca_system_score_gemma":0.0003149237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005269274,"about_ca_topic_score_gemma":0.0007156334,"domain_scores_codex":[0.9997298,0.0000476364,0.00001521854,0.00005558383,0.00007889205,0.00007283238],"domain_scores_gemma":[0.999926,0.00001233124,0.000009837152,0.000008032051,0.00002168013,0.00002208874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002138978,0.00009630276,0.0002607669,0.00007377173,0.00001850391,0.0001480027,0.00002137401,0.0008441198,0.9869359,0.0002469562,0.0006053558,0.0105351],"study_design_scores_gemma":[0.00007923581,0.0006270168,0.001571818,0.00001299047,0.00005724083,0.0005843199,0.00001607713,0.003561746,0.9844897,0.00009620993,0.008887152,0.0000165923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9223465,0.003015253,0.06188958,0.0001537117,0.0000722267,0.0006309146,0.00330919,0.0007955776,0.007787006],"genre_scores_gemma":[0.9419422,0.001903248,0.04090479,0.0002806846,0.00003697721,0.0004502614,0.006918387,0.0001139066,0.007449499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001494832,"threshold_uncertainty_score":0.00500071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05193437058917561,"score_gpt":0.2839312611551878,"score_spread":0.2319968905660122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}