{"id":"W2137864841","doi":"10.1074/jbc.m303164200","title":"Human Combinatorial Fab Library Yielding Specific and Functional Antibodies against the Human Fibroblast Growth Factor Receptor 3","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"MorphoSys; School of Medicine, New York University; York University","keywords":"Antibody; Complementarity determining region; Monoclonal antibody; Immunoglobulin light chain; Molecular biology; Flow cytometry; Receptor; Recombinant DNA; Biology; Immunoglobulin Fab Fragments; Chemistry; Biochemistry; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000229409,0.0001883562,0.0003667642,0.00003681484,0.0003296581,0.00006601604,0.0001463751,0.0001899135,0.001829968],"category_scores_gemma":[0.0001782513,0.00009885096,0.0002069745,0.0001075691,0.0003951643,0.00009866581,0.00008916589,0.0007596174,0.0000073265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002933385,"about_ca_system_score_gemma":0.00005734631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001137467,"about_ca_topic_score_gemma":3.634981e-8,"domain_scores_codex":[0.9986684,0.00007955554,0.0004429881,0.0001928281,0.0003486661,0.0002676156],"domain_scores_gemma":[0.9991568,0.0001784345,0.0002019342,0.0001089946,0.0001261874,0.0002276278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001874469,0.0001640297,0.06029608,0.00009105045,0.00009858066,0.00006494356,0.00003470209,3.153817e-7,0.9269539,0.001713232,0.01022777,0.0001679902],"study_design_scores_gemma":[0.00238084,0.000879748,0.1773066,0.0003651548,0.00002689316,0.0006802175,0.0004200785,0.000001665024,0.745694,0.003415283,0.06848547,0.0003440549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881545,0.0009932083,0.000004202021,0.001007293,0.0001713129,0.00007714669,0.00001954837,0.00001613817,0.009556658],"genre_scores_gemma":[0.9962925,0.0006850194,0.0001473888,0.0001758239,0.001362038,0.000001488042,0.00002602775,0.0000118217,0.001297913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1812598,"threshold_uncertainty_score":0.9990825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05193437058917561,"score_gpt":0.2839312611551878,"score_spread":0.2319968905660122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}