{"id":"W2137868544","doi":"10.1111/j.1750-3639.2008.00153.x","title":"Anti‐O6‐Methylguanine‐Methyltransferase (MGMT) Immunohistochemistry in Glioblastoma Multiforme: Observer Variability and Lack of Association with Patient Survival Impede Its Use as Clinical Biomarker*","year":2008,"lang":"en","type":"article","venue":"Brain Pathology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":242,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute","keywords":"Temozolomide; Immunohistochemistry; Oncology; Medicine; Methyltransferase; Tissue microarray; Biomarker; Cancer; Chemoradiotherapy; O-6-methylguanine-DNA methyltransferase; Methylation; Pathology; Glioblastoma; Internal medicine; Cancer research; Biology; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001174254,0.0002655901,0.0008467092,0.0001224611,0.00006461927,0.000008277385,0.00007060591,0.0003883061,0.00005242494],"category_scores_gemma":[0.003536245,0.000215166,0.0001467754,0.0003055537,0.0002329996,0.000112391,0.00005717374,0.0002900361,0.000008625705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001904625,"about_ca_system_score_gemma":0.00018491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001800945,"about_ca_topic_score_gemma":0.00005216448,"domain_scores_codex":[0.9973752,0.0005756427,0.0008186031,0.0005638077,0.0003036889,0.0003630041],"domain_scores_gemma":[0.9969486,0.00194279,0.0002775142,0.0004067457,0.0002622726,0.0001620677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001184366,0.001722645,0.8825286,0.00007804903,0.0001420968,0.001357278,0.0003766826,0.000003668235,0.1111286,0.00003338315,0.0001294434,0.001315235],"study_design_scores_gemma":[0.007017531,0.001743321,0.9500871,0.00007231651,0.0001108922,0.0004934897,0.00007586667,0.00006893747,0.03998719,0.00001761998,0.0001349224,0.0001907633],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980758,0.0001736867,0.00001958012,0.0007693451,0.0001270281,0.0006188792,0.00008431081,0.0000326708,0.00009864066],"genre_scores_gemma":[0.9983907,0.0002200453,0.0008682761,0.0003157576,0.00002468775,0.00005503061,0.00005185039,0.00002738763,0.00004629932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07114138,"threshold_uncertainty_score":0.8774217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05118010176434421,"score_gpt":0.3373131823138463,"score_spread":0.2861330805495021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}