{"id":"W2137868544","doi":"10.1111/j.1750-3639.2008.00153.x","title":"Anti‐O6‐Methylguanine‐Methyltransferase (MGMT) Immunohistochemistry in Glioblastoma Multiforme: Observer Variability and Lack of Association with Patient Survival Impede Its Use as Clinical Biomarker*","year":2008,"lang":"en","type":"article","venue":"Brain Pathology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":242,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute","keywords":"Temozolomide; Immunohistochemistry; Oncology; Medicine; Methyltransferase; Tissue microarray; Biomarker; Cancer; Chemoradiotherapy; O-6-methylguanine-DNA methyltransferase; Methylation; Pathology; Glioblastoma; Internal medicine; Cancer research; Biology; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02732879,0.0004521212,0.0007020151,0.001473182,0.000494027,0.0008060352,0.0005394208,0.000707982,0.0004773156],"category_scores_gemma":[0.02797511,0.000354133,0.0004624554,0.001091936,0.0009541506,0.0007872765,0.001229022,0.0004681917,0.0002048928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004602374,"about_ca_system_score_gemma":0.0003376902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001083429,"about_ca_topic_score_gemma":0.002213123,"domain_scores_codex":[0.9796485,0.01025108,0.002704537,0.002805634,0.003890122,0.0006999485],"domain_scores_gemma":[0.9510379,0.0319038,0.006417219,0.00481826,0.005212579,0.0006102837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00124571,0.00009032246,0.916824,0.0002264057,0.0005154457,0.0002659839,0.0008653836,0.001222292,0.04610988,0.000138229,0.0002302667,0.03226605],"study_design_scores_gemma":[0.00003696868,0.0006014581,0.9671642,0.00003772336,0.0003235825,0.001537232,0.0003699139,0.00941943,0.01875097,0.0005709401,0.0011439,0.00004362506],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788406,0.002395719,0.01743617,0.00007672433,0.00005044495,0.00006878167,0.00007924964,0.00005715049,0.0009952573],"genre_scores_gemma":[0.995278,0.0001577815,0.004169214,0.00003948301,0.00003562716,0.00004033861,0.00009551405,0.0000284309,0.000155692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02732879,"threshold_uncertainty_score":0.1445302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05118010176434421,"score_gpt":0.3373131823138463,"score_spread":0.2861330805495021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}