{"id":"W2137927119","doi":"10.2337/db11-0944","title":"miR-33a Modulates ABCA1 Expression, Cholesterol Accumulation, and Insulin Secretion in Pancreatic Islets","year":2012,"lang":"en","type":"article","venue":"Diabetes","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"ABCA1; Internal medicine; Endocrinology; Insulin; Islet; Biology; Pancreatic islets; Downregulation and upregulation; Insulin oscillation; Glucose homeostasis; Cholesterol; Diabetes mellitus; Insulin resistance; Transporter; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002788248,0.0001774564,0.0003421222,0.0001612944,0.00004795566,0.00002785094,0.00004830182,0.0001268568,0.00005423705],"category_scores_gemma":[0.0001506498,0.0001454833,0.00004186589,0.0001611138,0.00004975487,0.0003682508,0.0000444342,0.0001642994,0.00004139479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002292072,"about_ca_system_score_gemma":0.0000117143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000202746,"about_ca_topic_score_gemma":0.000001578457,"domain_scores_codex":[0.998866,0.00007175295,0.0002968776,0.0002206992,0.0001780533,0.000366624],"domain_scores_gemma":[0.9993522,0.0000853658,0.00007806606,0.0002416228,0.00004550441,0.0001972452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00002220563,0.0001337093,0.8530198,0.0001076295,0.00001414581,5.546817e-7,0.001261468,0.00001206857,0.1399555,0.00001985032,0.0001246884,0.005328354],"study_design_scores_gemma":[0.001716617,0.00003490013,0.9526778,0.0002786705,0.00005124562,0.000003334978,0.00007474556,0.0008230467,0.03999192,0.0001634283,0.004040774,0.0001435431],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949443,0.003925208,0.00001444336,0.0003521725,0.000198703,0.0003267786,0.000005810094,0.00008233494,0.0001502287],"genre_scores_gemma":[0.9982152,0.0001210742,0.0003062449,0.0006779783,0.0004526287,0.00004886254,0.00006202214,0.00003371185,0.00008227686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09996362,"threshold_uncertainty_score":0.5932636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02175835615048829,"score_gpt":0.2752997632846604,"score_spread":0.2535414071341722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}