{"id":"W2137991989","doi":"10.1093/toxsci/kft274","title":"Zinc Finger Nuclease–Mediated Knockout of AHR or ARNT in Human Breast Cancer Cells Abolishes Basal and Ligand-Dependent Regulation of CYP1B1 and Differentially Affects Estrogen Receptor α Transactivation","year":2013,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Transactivation; Aryl hydrocarbon receptor nuclear translocator; Estrogen receptor; Basal (medicine); Biology; Breast cancer; Knockout mouse; Endocrinology; Internal medicine; Estrogen; Cancer research; CYP1B1; Chemistry; Receptor; Cell biology; Cancer; Transcription factor; Genetics; Medicine; Aryl hydrocarbon receptor; Gene; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001644258,0.0003478243,0.0002780888,0.0003091375,0.0001672427,0.0003136661,0.000172723,0.0002701397,0.001676123],"category_scores_gemma":[0.0001077535,0.0002077155,0.0003170001,0.0002557678,0.000272287,0.0001410258,0.0001818558,0.000529509,0.0007667599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002617367,"about_ca_system_score_gemma":0.0002125045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001347797,"about_ca_topic_score_gemma":0.002013263,"domain_scores_codex":[0.999728,0.00002870645,0.00002529024,0.00006124235,0.00009682046,0.00005996425],"domain_scores_gemma":[0.9998845,0.00001965268,0.00003394364,0.00002272505,0.00001181373,0.000027406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004332156,0.00001084031,0.0001401143,0.000012844,0.000003835265,0.00003561357,0.000007152555,0.00003029118,0.9991837,0.0000480179,0.00002197369,0.0004622278],"study_design_scores_gemma":[0.00001149229,0.0001284961,0.003834796,0.000002624109,0.00001875628,0.0004490813,0.00002330915,0.0005011976,0.9909638,0.00002667694,0.004035481,0.000004309771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886496,0.001823302,0.006460862,0.0001276496,0.00005233804,0.00004448727,0.001211774,0.0002242911,0.001405698],"genre_scores_gemma":[0.9847664,0.001350098,0.005149961,0.00006927757,0.00001186498,0.00006055679,0.002367084,0.00004426404,0.006180563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001676123,"threshold_uncertainty_score":0.005607128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01453491448756708,"score_gpt":0.2612813736720356,"score_spread":0.2467464591844686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}