{"id":"W2137991989","doi":"10.1093/toxsci/kft274","title":"Zinc Finger Nuclease–Mediated Knockout of AHR or ARNT in Human Breast Cancer Cells Abolishes Basal and Ligand-Dependent Regulation of CYP1B1 and Differentially Affects Estrogen Receptor α Transactivation","year":2013,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Transactivation; Aryl hydrocarbon receptor nuclear translocator; Estrogen receptor; Basal (medicine); Biology; Breast cancer; Knockout mouse; Endocrinology; Internal medicine; Estrogen; Cancer research; CYP1B1; Chemistry; Receptor; Cell biology; Cancer; Transcription factor; Genetics; Medicine; Aryl hydrocarbon receptor; Gene; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002158996,0.00009241568,0.0001529651,0.00004395963,0.00006040703,0.00002575212,0.00008212694,0.0001329804,0.0001268084],"category_scores_gemma":[0.00004027781,0.0000630834,0.00002209672,0.0001061859,0.0002558045,0.00001503103,0.00003593182,0.00004177188,3.249581e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008456361,"about_ca_system_score_gemma":0.00003412275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001643565,"about_ca_topic_score_gemma":0.000134772,"domain_scores_codex":[0.999189,0.00007778654,0.0001980436,0.0002516802,0.000146973,0.0001365639],"domain_scores_gemma":[0.9996561,0.00004859246,0.000128284,0.00006216183,0.00004734648,0.00005751372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004616108,0.0000829048,0.01548557,0.00001676876,0.000005806116,9.809651e-8,0.00005761994,0.000117616,0.9783605,0.00003060958,0.000008822129,0.005787523],"study_design_scores_gemma":[0.0002427147,0.0003575625,0.3617705,0.00001565766,0.000005320986,2.287661e-7,0.00002992004,0.000224768,0.6371025,0.0001773957,0.00001150751,0.00006195779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991135,0.0002509549,0.000104518,0.0001546125,0.00003916211,0.000238776,0.00001825867,0.000003688554,0.0000765492],"genre_scores_gemma":[0.9991992,0.0003903041,0.0002915566,0.00002106887,0.00003364224,0.00001748729,0.000009544467,0.000003892801,0.00003333847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3462849,"threshold_uncertainty_score":0.2572466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01453491448756708,"score_gpt":0.2612813736720356,"score_spread":0.2467464591844686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}