{"id":"W2137996608","doi":"10.1158/0008-5472.can-06-3332","title":"Intraprostatic Androgens and Androgen-Regulated Gene Expression Persist after Testosterone Suppression: Therapeutic Implications for Castration-Resistant Prostate Cancer","year":2007,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":524,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; Immunovaccine (Canada)","funders":"National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Aging; National Cancer Institute; Prostate Cancer Foundation; National Institutes of Health; Michael Smith Health Research BC; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Oregon National Primate Research Center; National Institute of Child Health and Human Development; U.S. Department of Veterans Affairs","keywords":"Prostate cancer; Androgen; Androgen deprivation therapy; Medicine; Androgen receptor; Internal medicine; Endocrinology; Testosterone (patch); Prostate; TMPRSS2; LNCaP; Cancer research; Cancer; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002780795,0.0001839518,0.0003785787,0.0001872232,0.0001261728,0.0003975751,0.0001758856,0.0001994804,0.0007974154],"category_scores_gemma":[0.0002068686,0.00008018421,0.0002405858,0.0002695038,0.0003339871,0.000239643,0.00007566858,0.0004119058,0.0001680115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002828457,"about_ca_system_score_gemma":0.0002420271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004419123,"about_ca_topic_score_gemma":0.001254211,"domain_scores_codex":[0.9998956,0.00002345035,0.00000607634,0.00001693533,0.00003485239,0.00002309496],"domain_scores_gemma":[0.9998841,0.00001933375,0.00004502242,0.00001170856,0.00001439317,0.00002535201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003475588,0.0005687361,0.006539049,0.0002754472,0.00003440056,0.000169325,0.00008773323,0.0003033349,0.9302266,0.0002275067,0.0003274058,0.05776482],"study_design_scores_gemma":[0.0004155897,0.02053429,0.5103388,0.00007767174,0.0003565575,0.00204595,0.0003955021,0.002879278,0.4442242,0.0005310771,0.01814609,0.00005501278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9528033,0.0434195,0.001324409,0.0005571274,0.00009050497,0.0000280157,0.0002133001,0.0000581536,0.001505694],"genre_scores_gemma":[0.9916437,0.006501228,0.0004456397,0.0001217153,0.00009245832,0.00001601074,0.0001801872,0.000006997991,0.0009920887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007974154,"threshold_uncertainty_score":0.002667665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0799958214474921,"score_gpt":0.4127913581025604,"score_spread":0.3327955366550683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}