{"id":"W2137996608","doi":"10.1158/0008-5472.can-06-3332","title":"Intraprostatic Androgens and Androgen-Regulated Gene Expression Persist after Testosterone Suppression: Therapeutic Implications for Castration-Resistant Prostate Cancer","year":2007,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":524,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; Immunovaccine (Canada)","funders":"National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Aging; National Cancer Institute; Prostate Cancer Foundation; National Institutes of Health; Michael Smith Health Research BC; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Oregon National Primate Research Center; National Institute of Child Health and Human Development; U.S. Department of Veterans Affairs","keywords":"Prostate cancer; Androgen; Androgen deprivation therapy; Medicine; Androgen receptor; Internal medicine; Endocrinology; Testosterone (patch); Prostate; TMPRSS2; LNCaP; Cancer research; Cancer; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008929936,0.0002755879,0.0003621012,0.0003621997,0.0006242426,0.0001218489,0.0001466719,0.0001662765,0.0002730986],"category_scores_gemma":[0.00005306472,0.0002057335,0.00009229756,0.0006491066,0.0005492648,0.000180056,0.0001032568,0.0003930518,0.000005248777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005448938,"about_ca_system_score_gemma":0.000779464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001861072,"about_ca_topic_score_gemma":0.0003067793,"domain_scores_codex":[0.9970766,0.00009772478,0.0004084793,0.0007288626,0.0006162548,0.001072056],"domain_scores_gemma":[0.9976617,0.0002884378,0.00007872721,0.0004915328,0.0009381325,0.0005414799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006734997,0.0002073065,0.04184464,0.0004439134,0.0001848805,0.00005018919,0.001365425,0.00000442491,0.9264232,0.00004356344,0.001276102,0.02142137],"study_design_scores_gemma":[0.006515085,0.001180908,0.1794339,0.0006704216,0.0001810549,0.0000646585,0.0007703273,0.00006402531,0.80411,0.0005124373,0.00612768,0.0003694639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9593446,0.0301387,0.0001238011,0.006037617,0.0001040579,0.003503541,0.0005928628,0.00005935764,0.00009551703],"genre_scores_gemma":[0.9897304,0.003133027,0.0006369299,0.0001641095,0.0002355553,0.0034251,0.0001849817,0.00007516532,0.002414767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1375893,"threshold_uncertainty_score":0.8389567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0799958214474921,"score_gpt":0.4127913581025604,"score_spread":0.3327955366550683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}