{"id":"W2137996940","doi":"10.1186/1471-2121-9-59","title":"Aggresomes do not represent a general cellular response to protein misfolding in mammalian cells","year":2008,"lang":"en","type":"article","venue":"BMC Cell Biology","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"University of California, San Diego","keywords":"Aggresome; Cell biology; Protein aggregation; Biology; Protein folding; Inclusion bodies; Histone deacetylase; Ubiquitin; Histone; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005234059,0.0002794693,0.0002815159,0.0001783448,0.0001228489,0.00002056106,0.0004047282,0.0003045584,0.0001305429],"category_scores_gemma":[0.0002010309,0.0002754279,0.0001801638,0.000204318,0.00009839243,0.000004352969,0.0003403954,0.0001380986,0.00008899446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004222987,"about_ca_system_score_gemma":0.0001847636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001399452,"about_ca_topic_score_gemma":0.00003248437,"domain_scores_codex":[0.9975142,0.0005240492,0.0004030022,0.0008281613,0.0001211536,0.0006093846],"domain_scores_gemma":[0.9988486,0.0000401154,0.0001199165,0.0006846299,0.00005107382,0.0002556656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00187708,0.00008528059,0.00736958,0.00002599631,0.000009792911,0.00007489725,0.00007218608,0.0003054578,0.9880973,0.00001865234,0.0006366042,0.001427211],"study_design_scores_gemma":[0.0008833123,0.0003894038,0.002683911,0.00002053079,0.000005480849,0.00001120212,0.00003562094,0.00004358907,0.9046931,0.00003725822,0.09084738,0.0003492408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930085,0.004995118,0.0005941239,0.0001899071,0.000155459,0.0007593569,0.00003782636,0.00002287749,0.0002368559],"genre_scores_gemma":[0.9916553,0.0003773382,0.004906824,0.0003933567,0.0002923974,0.0001724917,0.00005692438,0.00003816704,0.002107132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09021078,"threshold_uncertainty_score":0.9999698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01793838359603731,"score_gpt":0.2554919822577496,"score_spread":0.2375535986617122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}