{"id":"W2137999973","doi":"10.1261/rna.033100.112","title":"Cas5d processes pre-crRNA and is a member of a larger family of CRISPR RNA endonucleases","year":2012,"lang":"en","type":"article","venue":"RNA","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Basic Energy Sciences; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Office of Science; National Institutes of Health; Eli Lilly and Company; U.S. Department of Energy","keywords":"Trans-activating crRNA; CRISPR; Biology; Genetics; RNA; CRISPR interference; Endonuclease; RNA silencing; Gene; DNA; Computational biology; Cas9; Nucleic acid; RNA interference","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001526501,0.000649403,0.0005234483,0.0005405665,0.0004664413,0.0005921716,0.0005358551,0.0005544231,0.00176478],"category_scores_gemma":[0.0002176602,0.0001899764,0.0005889376,0.0003730704,0.0004140105,0.0003128651,0.0003410643,0.0004630851,0.001231194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008926594,"about_ca_system_score_gemma":0.0003957076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001617749,"about_ca_topic_score_gemma":0.001273259,"domain_scores_codex":[0.9997119,0.00001929966,0.00002536597,0.0001040228,0.0001028658,0.00003647607],"domain_scores_gemma":[0.9998643,0.0000231701,0.00003899489,0.00002014282,0.00001894768,0.00003436755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000183236,0.00004131423,0.001855968,0.0002564861,0.00002344373,0.0003400359,0.00003491977,0.0005960354,0.9788265,0.001412326,0.0005244014,0.01590532],"study_design_scores_gemma":[0.0000110543,0.00009356721,0.004936207,0.000009981891,0.00001238628,0.001006866,0.00003158012,0.003552073,0.9656794,0.0003187682,0.02433051,0.00001748955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7884724,0.01300427,0.1741736,0.0005145082,0.0003473295,0.0003537148,0.00437848,0.003062859,0.01569291],"genre_scores_gemma":[0.9364898,0.00174299,0.04981259,0.0001509754,0.00001913001,0.00006153878,0.003484585,0.0001072647,0.008131324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00176478,"threshold_uncertainty_score":0.0064767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01119678347638355,"score_gpt":0.2977407345515101,"score_spread":0.2865439510751265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}